Therapeutic Effect of Gu Hong Injection on Angina Pectoris after PCI in Patients with Coronary Heart Disease and its Influence on Inflammatory Reaction and Vascular Endothelial Function
FU Qiang,QI Ji
Department of Cardiovascular Medicine, Shenyang 4th People's Hospital, Shenyang, Liaoning 110031
Abstract：【Objective】To investigate the therapeutic effect of Gu Hong Injection on angina pectoris after percutaneous coronary intervention (PCI) in patients with coronary heart disease and its influence on inflammatory reaction and vascular endothelial function.【Methods】From January 2014 to December 2016, 114 patients with angina pectoris treated by PCI operation in our hospital were selected.According to the random number method; they were divided into observation group and control group with 57 cases in each group. Patients in the control group were treated with aspirin enteric-coated tablets, clopidogrel sulfate tablets, isosorbide mononitrate tablets and metoprolol tartrate tablets. The observation group was treated with Gu Hong Injection on the basis of the use of the control group. All the patients were treated for 2 weeks. The frequency and duration of angina pectoris before and after treatment were compared between the two groups. The therapeutic effect of angina pectoris was evaluated. Levels of serum Hs-CRP, tumor necrosis factor -α (TNF-α), interleukin-6 (IL-6) and endothelin-1 (ET-1) and nitric oxide (no) were compared between the two groups before and after treatment. At the same time, Doppler color ultrasound was used to evaluate vascular endothelium-dependent diastolic (FMD) function.【Results】After treatment, the attack frequency and duration of angina pectoris in the two groups were lower than those before treatment, and the attack frequency and duration of angina pectoris in the observation group were significantly lower than those in the control group. The difference was statistically significant (P<0.05). The total effective rate of treatment in the observation group was 91.2% (52/ 57), which was significantly higher than that in the control group 82.5% (47/ 57), and the difference was statistically significant (χ2=5.368, P<0.05). After treatment, the levels of serum Hs-CRP, TNF-and IL-6 were significantly decreased in both groups. The level of serum Hs-CRP, TNF-and IL-6 in the observation group was significantly lower than that in the control group (P<0.05). After treatment, the serum ET-1 level in the two groups was significantly decreased, the levels of NO and FMD increased significantly; the serum ET-1 level in the observation group was significantly lower than that in the control group. The NO and FMD were significantly higher than those of the control group, the difference was statistically significant (P<0.05). 【Conclusion】On the basis of routine treatment after PCI operation for coronary heart disease, Guhong injection significantly reduce the frequency of recurrent angina pectoris after PCI and the level of serum inflammatory factors, and improve vascular endothelial function.
付强,齐霁. 谷红注射液辅助治疗冠心病患者PCI术后再发心绞痛的临床疗效及其对炎性因子和血管内皮功能的影响[J]. 医学临床研究, 2018, 35(1): 79-82.
FU Qiang,QI Ji. Therapeutic Effect of Gu Hong Injection on Angina Pectoris after PCI in Patients with Coronary Heart Disease and its Influence on Inflammatory Reaction and Vascular Endothelial Function. JOURNAL OF CLINICAL RESEARCH, 2018, 35(1): 79-82.
[1] Woo JS,Kim W,Jang HH,et al.Effect of platelet reactivity,endothelial function,and inflammatory status on outcomes in patients with stable angina pectoris on clopidogrel therapy[J].Am J Cardiol,2014,113(5):786-792. [2] Duttaroy S,Nilsson J,Hammarsten O,et al.High frequency home-based exercise decreases levels of vascular endothelial growth factor in patients with stable angina pectoris[J].Eur J Prev Cardiol,2015,22(5):575-581. [3] Jedlickova L,Merkovska L,Jackova L,et al.Effect of ivabradine on endothelial function in patients with stable angina pectoris: assessment with the Endo-Pat 2000 device[J].Adv Ther,2015,32(10):962-970. [4] 金燕,王晓琴.经桡动脉介入治疗冠心病患者的围手术期护理体会[J].转化医学电子杂志,2016,3(5):84-85. [5] 陈峰,张顺利,李迎.冠心舒通胶囊联合黛力新治疗冠心病PCI术后心绞痛的疗效观察[J].中西医结合心血管病电子杂志,2015,26(8):91-92. [6] 郝俊华,宁晓红.通心络胶囊治疗老年冠心病经皮冠状动脉介入治疗术后心绞痛临床观察[J].河北中医,2015,33(6):897-900. [7] 刘亚林,刘飞君.冠心宁联合谷红对不稳定型心绞痛PCI术后血小板功能的影响及心肌保护作用[J].中国现代医生,2016,54(3):13-16. [8] 张春,米忠友,田维君.硫酸氢氯吡格雷片联合阿托伐他汀钙胶囊、养心氏片治疗冠心病PCI术后心绞痛39例临床疗效观察[J].世界中医药,2014,28(10):1299-1301. [9] Kabakli A,Fras Z.Moderate-dose atorvastatin improves arterial endothelial function in patients with angina pectoris &normal coronary angiogram: a pilot study[J].Arch Med Sci,2017,13(4):827-836. [10] 柳万千,殷锡虎,敖钦,等.丹红注射液配合调脂治疗对冠心病心绞痛患者血管内皮功能的影响[J].上海医药,2014,39(21):42-45. [11] Barrett M,Heracleous L,Walsham G.Effect of tumor necrosis factor inhibitor treatment on proximal right coronary chronic total occlusion in a patient with rheumatoid arthritis[J].Circulation,2015,131(4):26-28. [12] 何昱.HPLC-DAD法同时测定谷红注射液中7个组分的含量[J].药物分析杂志,2015,28(6):954-959. [13] 舒明春,万海同,周惠芬,等.谷红注射液抗脑缺血性再灌注损伤的作用及其机制[J].中国中药杂志,2014,39(24):4829-4833. [14] 白洁,张可勇,徐亚茹,等.谷红注射液对非痴呆性血管认知障碍的疗效以及对脂蛋白相关磷脂酶A2的影响[J].中国医院药学杂志,2014,34(16):1374-1378. [15] 郭晓叶.浅析谷红注射液治疗冠心病心绞痛临床效果[J].中国保健营养,2017,27(2):15. [16] 何仲春,肖慧宇,石顺华,等.血栓通联合低分子肝素治疗对急性冠脉综合征患者PCI术后炎症因子及内皮功能的影响[J].现代生物医学进展,2017,17(18):3540-3543. [17] 冯奇桃,王日兴,陈士军.丹红注射液配合调脂治疗对冠心病心绞痛患者血管内皮功能的影响[J].中华中医药学刊,2017,35(9):2412-2414.
2018, Vol. 35 
