Abstract：【Objective】To evaluate the prognostic value of free fatty acid (FFA) levels in cerebrospinal fluid (CSF) of patients d with acute ischemic stroke (AIS).【Methods】A total of 321 cases of acute ischemic stroke patients from January 2012 to December 2015 in our hospital were selected as study subjects. The National Institutes of Health Stroke Scale (NIHSS) score on admission was applied to assess specific severity degree of stroke. The levels of FFA from CSF and serum were measured using an enzyme cycling method. The prognostic outcomes of those stroke patients were evaluated by the modified Rankin scale scores 90days after admission. The prognostic value of FFA was analyzed by Logistic regression analysis.【Results】There was a positive relationship between CSF FFA and NIHSS score.Additionally, there was a positive relationship between the severity of stroke and serum levels of FFA. The FFA levels of CSF and serum in 231 patients with favorable outcome were significantly lower than those in 90 patients with unfavorable outcomes (P<0.05). The FFA levels of CSF and serum in 272 cases of survival patients were significantly lower than those in 49 dead patients (P<0.05). Multivariate analysis results showed that there was an increased risk of unfavorable outcome associated with FFA level in CSF ≥0.301 mmol/L (OR=5.28, P<0.0001).【Conclusion】The FFA level in CSF at admission was suggested to be an independent short-term prognostic marker in patient with AIS.
张博文,刘海花,张小庆,尹云霞,王峰,刘立娜,郑丽丽. 脑脊液中游离脂肪酸水平在急性缺血性脑卒中的预后价值[J]. 医学临床研究, 2018, 35(1): 73-75,78.
ZHANG Bo-wen,LIU Hai-hua,ZHANG Xiao-qing,et al. Prognostic Value of Free Fatty Acid Level in the Cerebrospinal Fluid of Patients with Acute Ischemic Stroke. JOURNAL OF CLINICAL RESEARCH, 2018, 35(1): 73-75,78.
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