Abstract：【Objective】To investigate the effect of inhalation anesthesia on E-selectin, matrix metalloproteinase (MMP) and immune function recovery in patients with lung cancer .【Methods】Eighty-six cases of radical resection of lung cancer were selected in our hospital and were randomly divided into sevoflurane group (n=43) and isoflurane group (n=43). The levels of E-selectin, MMP-2, MMP-9, interleukin-6 (IL-6), tumor necrosis factor -ɑ and soluble interleukin-2 receptor (sIL-2R) were monitored and compared at the time of anesthesia induction (T0), 1h after operation start (T1), 2h (T2) and 1h after operation (T3).【Results】The serum levels of E-selectin, MMP-2, MMP-9 and TNF-ɑ in the group A were lower than those in group B at time of T1、T2、T3 (P<0.05). The level of serum IL-6 in the group A was lower than that in group B at time of T1, T2 and T3 (P<0.05).There was no significant difference in the level of sIL-2R between the two groups at each time point (P>0.05).【Conclusion】Sevoflurane inhalation anesthesia can effectively inhibit the increase of E-selectin, MMP-2 and MMP-9, which is beneficial to the recovery of the immune function of the patients.
王华. 七氟醚对肺癌根治术患者血清E-选择素、基质金属蛋白酶及免疫功能的影响[J]. 医学临床研究, 2018, 35(1): 59-61.
WANG Hua. Effects of Inhalation Anesthesia on E-selectin , Matrix Metalloproteinase (MMP) and Immune Function Recovery in Patients with Lung Cancer. JOURNAL OF CLINICAL RESEARCH, 2018, 35(1): 59-61.
2018, Vol. 35 
