Effect of Ginkgo Biloba Extract Combined with Comprehensive Audiovisual Training on Plasma Nitric Oxide, Oxidative Stress and Exercise Capacity in Patients with Parkinson's Disease
ZHOU Li,JIANG Hua,SHEN Liu-yan,et al
Department of Neurology, Luzhou People's Hospital, Luzhou 646000, Sichuan Province, China
Abstract：【Objective】To observe the effect of Ginkgo biloba extract combined with comprehensive visual and auditory training on the levels of plasma nitric oxide (NO), reduction of oxidative stress and capacity of exercise in patients with Parkinson's disease (PD).【Methods】A total of 60 patients with primary PD admitted to the Department of Neurology in the hospital during May 2014 to May 2016 were enrolled in the study. The patients were evenly divided into the observation group and the control group using a random number table, with 30 cases in each group. Patients in the control group weregiven Ginkgo biloba extract injectionswhile patients in the observation group were given visual and auditory combined training on the basis of Ginkgo biloba extract injections. After 3 months of treatment, the levels of serum vasoactive substances [ (NO, endothelin (ET)], indices of oxidative stress [superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), malondialdehyde (MDA)], scores on the Unified Parkinson's Disease Rating Scale (UPDRS) Part Ⅲ (UPDRS Ⅲ), scores on the Berg balance, and rates of adverse reactions during treatment were compared between the two groups.【Results】After treatment, NO, ET, SOD, MDA and GSH-Px changed significantly. NO, SOD and GSH-Px were significantly higher in the observation group than the control group (P<0.05) while ET and MDA were significantly lower than the control group (P<0.05). After treatment, the UPDRS Ⅲ score of the observation group was significantly lower and the Berg balance score was significantly higher than those of the control group (P<0.05). After treatment, the walk test time was significantly shorter in the observation group than the control group, and 6 minutes walking distance, stride length and walking speed were significantly higher in the observation group than the control group (P<0.05). There was no significant change of frequency in the two groups before and after treatment (P>0.05). There was no significant difference in the incidence of adverse reactions between the two groups during treatment (P>0.05).【Conclusion】Ginkgo biloba extract combined with audio-visual comprehensive training can significantly relieve oxidative stress as well as improve the balancing function and walking ability of patients. It is conductive to improving the motor function of patients and the low incidence of adverse reactions is low.
2018, Vol. 35 
