Study of the Correlation between the Distribution of Pathogens in Nasopharyngeal and Middle Ear Cavities in Children with Chronic Secretory Otitis Media
SONG Gui-lin, LI Xiang-sheng, PENG Ya, et al
Department of ENT, The Fourth People’s Hospital of Changsha, Changsha 410006, China
Abstract：【Objective】To analyze the distribution of pathogens and its correlation with middle ear fluid (MEF) and nasopharyngeal secretion (NPS) in children with chronic secretory otitis media (SOM) .【Methods】MEF and NPS secretions were collected from SOM children. The pathogen distribution of NPS and MEF were observed by PCR technique for detection of A.otitidis, S.pneumonia, H.influenzae, M.catarrhails, S.aureus, and S.viridans. The correlation was evaluated.【Results】1) The presence of S.pneumonia or S.aureus in middle earfiuid was significantly positively correlation with the presence of the same species in the nasopharynx (S.pneumoniae, P=0.000, V=0.638; S.aureus, P= 0.000, V=0.761) . Higher prevalence (Sensitivity, specificity and positive predictive values) was found for S.pneumonia and S.aureu S.H.influenzae or M.catarrhails in middle earfiuid correlated positively with the presence of the same species in the nasopharynx, however, the correlation was low (H.influenzae, P=0.021, V=0.258 M.catarrhails, P=0.000, V=0.459) . 2) Alloiococcus otitidis and Streptococcus viridans were not significantly associated with MEF and NPS PCR result S.3) The highest prevalence in NPS was found for H.influenzae (79.63%) , followed by S.aureus (75.93%) and S.pneumonia (75.93%) . The highest prevalence in MEF was found for S.pneumonia (75.93%) and S.aureus (75.93%) .【Conclusion】The results indicate that PCR results from NPS are valuable for prediction of the pathogen presence in MEF in children with SOM.
宋桂林,李湘胜,彭亚,李琴,柳浩,谢东海,陶维平,姚汉斌,邓晓雯,聂瑾,樊涛. 分泌性中耳炎患儿鼻咽部与中耳腔致病菌分布的相关性研究[J]. 医学临床研究, 2017, 34(11): 2081-2083,2087.
SONG Gui-lin, LI Xiang-sheng, PENG Ya, et al. Study of the Correlation between the Distribution of Pathogens in Nasopharyngeal and Middle Ear Cavities in Children with Chronic Secretory Otitis Media. JOURNAL OF CLINICAL RESEARCH, 2017, 34(11): 2081-2083,2087.
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