[1]Xia B,Shan M,Wang J,et al.Homeobox A11 hypermethylation indicates unfavorable prognosis in breast cancer[J].Oncotarget,2017,8(6):9794-9805. [2]Chang CJ,Chen YL,Hsieh CH,et al.HOXA5 and p53 cooperate to suppress lung cancer cell invasion and serve as good prognostic factors in non-small cell lung cancer[J].J Cancer,2017 ,8(6):1071-1081. [3]Esteller M.Cancer epigenomics: DNA methylomes and histone-modification maps[J].Nat Rev Genet,2007 ,8(4):286-298. [4]Wu SC,Zhang Y.Active DNA demethylation: many roads lead to Rome[J].Nat Rev Mol Cell Biol,2010 ,11(9):607-620. [5]Kim YJ,Yoon HY,Kim JS,et al.HOXA9,ISL1 and ALDH1A3 methylation patterns as prognostic markers for nonmuscle invasive bladder cancer: array-based DNA methylation and expression profiling[J].Int J Cancer,2013 ,133(5):1135-1142. [6]Cho HS,Toyokawa G,Daigo Y,et al.The JmjC domain-containing histone demethylase KDM3A is a positive regulator of the G1/Stransition in cancer cells via transcriptional regulation of the HOXA1 gene[J].Int J Cancer,2012,131(3):E179-E189. [7]Morice P,Leary A,Creutzberg C,et al.Endometrial cancer[J].Lancet,2016 ,387(10023):1094-1108. [8]Chen YC,Tsao CM,Kuo CC,et al.Quantitative DNA methylation analysis of selected genes in endometrial carcinogenesis[J].Taiwan J Obstet Gynecol,2015 ,54(5):572-579. [9]Fambrini M,Bussani C,Sorbi F,et al.Methylation of the HOXA10 homeobox gene promoter is associated with endometrial cancer: a pilot study[J].J Obstet Gynaecol,2013,33(5):519-520. [10]Xing BL,Li T,Tang ZH,et al.Cumulative methylation alternations of gene promoters and protein markers for diagnosis of epithelial ovarian cancer[J].Genet Mol Res,2015 ,14(2):4532-4540. [11]Wrangle J,Machida EO,Danilova L,et al.Functional identification of cancer-specific methylation of CDO1,HOXA9,and TAC1 for the diagnosis of lung cancer[J].Clin Cancer Res,2014,20(7):1856-1864. [12]Dietrich D,Hasinger O,Liebenberg V,et al.DNA methylation of the homeobox genes PITX2 and SHOX2 predicts outcome in non-small-cell lung cancer patients[J].Diagn Mol Pathol,2012,21(2):93-104. [13]Harada H,Miyamoto K,Yamashita Y,et al.Methylated DLX4 predicts response to pathologic stage i non-small cell lung cancer resection[J].Ann Thorac Surg,2015,99(5):1746-1754. [14]Zhang ML,Nie FQ,Sun M,et al.HOXA5 indicates poor prognosis and suppresses cell proliferation by regulating p21 expression in non small cell lung cancer[J].Tumour Biol,2015,36(5):3521-3531. [15]Chia NY,Tan P.Molecular classification of gastric cancer[J].Ann Oncol,2016,27(5):763-769. [16]Wang L,Chen S,Xue M,et al.Homeobox D10 gene,a candidate tumor suppressor,is downregulated through promoter hypermethylation and associated with gastric carcinogenesis[J].Mol Med,2012,18:389-400. [17]Kameoka Y,Kitazawa R,Ariasu K,et al.Reactivation of CDX2 in gastric cancer as mark for gene silencing memory[J].Acta Histochem Cytochem,2015,48(4):115-124. [18]Vinarskaja A,Schulz WA,Ingenwerth M,et al.Association of PITX2 mRNA down-regulation in prostate cancer with promoter hypermethylation and poor prognosis[J].Urol Oncol,2013,31(5):622-627. [19]Litovkin K,Joniau S,Lerut E,et al.Methylation of PITX2,HOXD3,RASSF1 and TDRD1 predicts biochemical recurrence in high-risk prostate cancer[J].J Cancer Res Clin Oncol,2014,140(11):1849-1861. [20]Gao F,Huang HJ,Gao J,et al.GSH2 promoter methylation in pancreatic cancer analyzed by quantitative methylation-specificpolymerase chain reaction[J].Oncol Lett,2015,10(1):387-391. [21]Zhang R,Kang KA,Kim KC,et al.Oxidative stress causes epigenetic alteration of CDX1 expression in colorectal cancer cells[J].Gene,2013 ,524(2):214-219. [22]Wan Abdul Rahman WF,Fauzi MH,Jaafar H.Expression of DNA methylation marker of paired-like homeodomain transcription factor 2 and growth receptors in invasive ductal carcinoma of the breast[J].Asian Pac J Cancer Prev,2014,15(19):8441-8445. [23]Pilato B,Pinto R,De Summa S,et al.HOX gene methylation status analysis in patients with hereditary breast cancer[J].J Hum Genet,2013,58(1):51-53. [24]Zhong Z,Shan M,Wang J,et al.HOXD13 methylation status is a prognostic indicator in breast cancer[J].Int J Clin Exp Pathol,2015 ,8(9):10716. [25]Uchida K,Veeramachaneni R,Huey B,et al.Investigation of HOXA9 promoter methylation as a biomarker to distinguish oral cancer patients at low risk of neck metastasis[J].BMC Cancer,2014 ,14:353. [26]Guerrero-Preston R,Soudry E,Acero J,et al.NID2 and HOXA9 promoter hypermethylation as biomarkers for prevention and early detection in oral cavity squamous cell carcinoma tissues and saliva[J].Cancer Prev Res (Phila),2011,4(7):1061-1072. [27]Hayashi M,Wu G,Roh JL,et al.Correlation of gene methylation in surgical margin imprints with locoregional recurrence in head and neck squamous cell carcinoma[J].Cancer,2015 ,121(12):1957-1965. [28]Lu J,Song G,Tang Q,et al.IRX1 hypomethylation promotes osteosarcoma metastasis via induction of CXCL14/NF-κB signaling[J].J Clin Invest,2015,125(5):1839-1856. [29]Kuo CC,Lin CY,Shih YL,et al.Frequent methylation of HOXA9 gene in tumor tissues and plasma samples from human hepatocellular carcinomas[J].Clin Chem Lab Med,2014,52(8):1235-1245.