Abstract：【Objective】To investigate the risk factors of nasopharyngeal ulcer after radical intensity modulated radiation therapy (IMRT) for nasopharyngeal carcinoma.【Methods】A retrospective analysis of 80 nasopharyngeal carcinoma patients (ulcer group) with nasopharyngeal ulcer 1 year after radical IMRT was performed in our hospital from August 2014 to August 2015.At the same time, clinical data of 80 patients with nasopharyngeal carcinoma (non ulcer group) without nasopharyngeal ulcer 1 year after radical IMRT was also analyzed(P＜0.05).【Results】There was no significant difference between the two groups in age, sex, education level, N stage, drinking status and so on (P＞0.05). Single factor analysis showed that T staging, chemotherapy, no nasal irrigation, nasopharynx dose＞72 Gy, no use of antibiotics, smoking, malnutrition were the dangerous factors of the incidence of nasopharyngeal ulcer after radical IMRT in nasopharyngeal carcinoma patients (P＜0.05).【Conclusion】T stage, chemotherapy, nasopharynx dosage ＞72 Gy, smoking, malnutrition and other factors are closely related to the incidence of nasopharyngeal ulcer after radical IMRT in nasopharyngeal carcinoma patients, which should be paid attention to.
2017, Vol. 34 
