Effect of Active Silver Ion Antibacterial Liquid on Oral Ulcer Induced by Chemotherapy and Plasma Cytokines in Children with Acute Lymphoblastic Leukemia
LI Jun-ling, YU Xiao-na, YAN Xiao-hong
Department of Stomatology, the Qingdao Central Hospital, Qingdao, Shandong, 266042
Abstract：【Objective】To investigate the effect of active silver ion antibacterial liquid on the prevention of oral ulcer and the cytokine in plasma of children with acute lymphoblastic leukemia.【Methods】A total of 118 cases of acute lymphoblastic leukemia diagnosed in our hospital from January 2015 to February 2017 were selected; according to the random number method, all the patients were randomly divided into the observation/study group (59 cases) and the control group (59 cases); all of the children completed the examination after admission and were treated with standard regimen for chemotherapy, routine oral nursing intervention during chemotherapy; the control group was given 0.9% saline or 1% hydrogen peroxide;on the basis of in the control group, the study group was treated with cleaning up by the active silver ion antibacterial mouthwash oral 5~10 ml, every time, gargle 5 min daily in the morning and evening and after meals each time, to those with oral ulcer recovery. The incidence of oral ulcers and the recovery time of oral ulcers were recorded and recorded in the two groups; the severity of oral ulcer was evaluated according to the standard of acute and subacute toxicity of anticancer drugs; at the same time before treatment and one week after treatment respectively, plasma interleukin -2 (IL-2) and interferon-g (IFN-g), tumor necrosis factor alpha (TNF- alpha) and other cytokines were determined by enzyme-linked immunosorbent assay (ELISA).【Results】The incidence rate of oral ulcer and oral ulcer recovery time of the study group with were significantly lower than the control group, the difference was statistically significant (P<0.05); oral ulcer severity of the study group was significantly lower than that of the control group, the two groups have statistical significance in children with oral ulcer severity difference (Z=25.162, P<0.05); after treatment, TNF-ɑ of the two groups of children was significantly decreased, IL-2 and IFN-g were significantly increased; after treatment, the level of TNF-ɑ of the study group was significantly lower than that of the control group, while the IL-2 and IFN-g levels were significantly higher than those the control group, the differences were statistically significant (P<0.05).【Conclusion】Active silver ion antibacterial liquid can effectively prevent children from acute lymphoblastic leukemia oral ulcers induced by chemotherapy, and promote the prognosis, improve plasma IL-2, IFN-g and TNF-ɑ levels, and enhance the immune function of children. It is worthy of clinical application.
李俊玲,于晓娜,闫晓红. 活性银离子抗菌液预防小儿白血病化疗后口腔溃疡的效果及其对患儿血浆细胞因子的影响[J]. 医学临床研究, 2017, 34(10): 1944-1947.
LI Jun-ling, YU Xiao-na, YAN Xiao-hong. Effect of Active Silver Ion Antibacterial Liquid on Oral Ulcer Induced by Chemotherapy and Plasma Cytokines in Children with Acute Lymphoblastic Leukemia. JOURNAL OF CLINICAL RESEARCH, 2017, 34(10): 1944-1947.
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2017, Vol. 34 
