Abstract：【Objective】To investigate the value of neoadjuvant interventional chemotherapy in the treatment of locally advanced cervical cancer and its effect on the expression of MMP-2, Fas and FasL cytokines.【Methods】A total of 60 cervical cancer patients in stage of IB ~ IIB, with tumor diameters greater than 4 cm were chosen for the study. They were randomly divided into groups A and B, each with 30 subjects. Patients in group A was treated with artery interventional neoadjuvant chemotherapy plus radical surgery, while patients in group B were treated with conventional intravenous chemotherapy plus radical surgery. The efficacy and occurrence of side effects were observed. The expression of MMP-2, Fas and FasL cytokines in two groups both before and after treatment was detected by immunohistochemistry.【Results】The effective rate of group A (83.33%) was significantly higher than that of group B (73.33%) (χ2=2.116, P=0.045). The effective rate of Ib was significantly higher than that of IIa and IIb; IIa was significantly higher than that of IIb; the effective rate of chemotherapy in patients with squamous cell carcinoma was significantly higher than that of adenocarcinoma; the efficiency of low differentiation of cervical cancer was significantly higher than that of middle differentiation and high differentiation (P<0.05). In group A, there were 14 cases of chemotherapy side effects, including vomiting /nausea (6 cases), moderate anemia (2 cases), hypogastrium pain (4 cases) and alopecia (2 cases). Group B had a total of 11 cases of side effects, consisting of vomiting /nausea (5 cases), moderate anemia (1 cases) and alopecia (5 cases). In this regard, there were no significant differences between the two groups (χ2=0.617, P>0.05). The positive rate of MMP-2 and FasL in the group A and group B after treatment were lower than before treatment, while the positive rate of Fas in group A and group B after treatment was significantly higher than before treatment (P<0.05). There were no significant differences of the positive rates of MMP-2, Fas and FasL in control group before and after treatment (P>0.05).【Conclusion】Neoadjuvant chemotherapy is effective in the treatment of locally advanced cervical cancer. MMP-2, Fas and FasL cytokines are closely related to cervical cancer cells.
戴规. 新辅助介入化疗在局部晚期宫颈癌治疗中的价值及对细胞因子表达的影响[J]. 医学临床研究, 2017, 34(10): 1916-1919.
DAI Gui. Value of Neoadjuvant Interventional Chemotherapy in the Treatment of Locally Advanced Cervical Cancer and Its Effect on Cytokine Expression. JOURNAL OF CLINICAL RESEARCH, 2017, 34(10): 1916-1919.
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2017, Vol. 34 
