Abstract:【Objective】To explore the curative effect evaluation of short-wave ultraviolet ray therapy for oral mucositis(OM) with acute leukemia patients.【Methods】Acute leukemia patients with oral mucositis were divided into the observation group and the control group according to the order of admission. Patients in the control group were treated by conventional methods, while patients in the observation group received irradiation treatment by ZYY - 9 enhanced short-wave ultraviolet ray therapy apparatus in addition to conventional treatment. The therapeutic effect for OM in the two groups was observed within 14 days.【Results】The recovery rate of the observation group was 89.3% which was obviously higher than that of the control group (64.3%) within 14 days, and the difference was statistically significant (P<0.001). In the observation group, the average time required for the disappearance of pain, the 50% reduction in ulcer area of OM and oral mucositis healing time were significantly shorter than those in the control group with statistically significant difference (P<0.001).【Conclusion】Short-wave ultraviolet irradiation treatment can obviously improve the recovery rate of OM and shorten its healing time. The instrument is convenient and safe to use with broad clinical popularization and application.