Effect of Ursodeoxycholic Acid Combined with Ademetionine on the Liver Function and Pregnancy Outcome in Patients with Intrahepatic Cholestasis of Pregnancy
LIU Yan
Obstetrics, the People's Hospital of Shapingba District, Chongqing 401120
Abstract：【Objective】To investigate the effect of ursodeoxycholic acid combined with methionine on liver function and pregnancy outcome in patients with intrahepatic cholestasis of pregnancy (ICP).【Methods】A total of 84 patients with ICP from February 2014 to October 2016 in our hospital were divided into two groups according to the treatment plan, each with a total of 42 cases. On the basis of conventional therapy, the control group was given ursodeoxycholic acid treatment, the observation group was given ursodeoxycholic acid + ademetionine treatment. Before and after treatment, serum total bile acid (TBA), liver function index [aspartate aminotransferase (AST), alanine aminotransferase (ALT) levels, pruritus (Ribalta) score, negative emotional anxiety (HAMA), depression (HAMD)] score of the two groups were compared. The pregnancy outcome and the neonatal Apgar score of the two groups were counted. 【Results】①serum TBA and liver function: before treatment, there was no significant difference in serum TBA, AST and ALT levels between the two groups (P＞0.05). After treatment, the serum levels of TBA, AST and ALT in the observation group were lower than those in the control group, the difference was statistically significant (P＜0.05);②pruritus: before treatment, there was no significant difference in Ribalta score between the two groups (P＞0.05). After treatment, the Ribalta scores of the two groups were reduced, and the observation group was lower than the control group, the difference was statistically significant (P＜0.05);③negative emotion: before treatment, there was no significant difference between the HAMA and HAMD scores of the two groups (P＞0.05). After treatment, the scores of HAMA and HAMD in the observation group were lower than those in the control group, the difference was statistically significant (P＜0.05);④pregnancy outcome and neonatal Apgar score: The rate of cesarean section, premature delivery and postpartum hemorrhage in the observation group was [28.57% (12/42), 9.52% (4/42), 4.76% (8/42), (2/42)], which were lower than those of the control group [50.00% (21/42), 26.19% (11/42), 19.05%(8/42)], Apgar score was higher than that of the control group, the difference was statistically significant (P＜0.05), There was no significant difference in the incidence of postpartum hemorrhage and neonatal asphyxia between the two groups (P＞0.05). 【Conclusion】Ursodeoxycholic acid combined with methionine treatment given for ICP patients can effectively reduce serum TBA levels, relieve itching symptoms, improve liver function and eliminate negative emotions, and thus help improve pregnancy outcomes.
刘燕. 熊去氧胆酸联合腺苷蛋氨酸对妊娠期肝内胆汁淤积症患者肝功能及妊娠结局的影响[J]. 医学临床研究, 2017, 34(8): 1523-1526.
LIU Yan. Effect of Ursodeoxycholic Acid Combined with Ademetionine on the Liver Function and Pregnancy Outcome in Patients with Intrahepatic Cholestasis of Pregnancy. JOURNAL OF CLINICAL RESEARCH, 2017, 34(8): 1523-1526.
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2017, Vol. 34 
