Abstract：【Objective】To evaluate Dexmedetomidine for its cerebral protective effects during anesthesia of heart valve replacement surgery. 【Methods】A total of 100 patients undergoing heart valve replacement under extracorporeal circulation were randomly divided into the observation group and the control group (n=50). Patients in the observation group received intravenous infusion of dexmedetomidine (1.0 μg/kg) 10 min before the induction of conventional anesthesia, followed by intravenous infusion of 0.5 μg/(kg·h) to the end of surgery. The control group received the same procedure with the same amount of saline. Carotid venous blood oxygen saturation (jugular venous oxygen saturation, SjvO2), internal jugular venous blood oxygen content (arterial venous oxygen content difference, Da-jvO2) and cerebral oxygen uptake rate (cerebral extraction of oxygen, CERO2) were recorded at the following time points: immediately before the start of extracorporeal circulation (T1), opening the ascending aorta (T2), 10 min after extracorporeal circulation ending(T3), 6 h after surgery (T4) and 24 h after surgery(T5). Meanwhile serum S-100β protein and neuron specific enolization enzyme (neuronspecific enolase, NSE) level were measured as well. 【Results】Compared to T1 time point, levels of SjvO2 and S-100β, NSE at other time points was significantly increased in both the observation group and the control group, while CERO2 was significantly decreased (P＜0.05). At T2 and T3, SjvO2 was significantly higher in the observation group than in the control group. Da-jvO2, CERO2, S-100β protein and NSE were significantly lower than in the control group (all P＜0.05).【Conclusion】Dexmedetomidine can improve cerebral oxygen metabolism, reduce cerebral ischemia and hypoxia and, to some extent, provide neuroprotective effects during anethesia of heart valve replacement surgery.
祁恒宁. 右美托咪定在心脏瓣膜置换手术麻醉中脑的保护作用[J]. 医学临床研究, 2017, 34(8): 1501-1503,1507.
QI Heng-ning. Protective Effects of Dexmedetomidine on the Brain during Anesthesia of Heart Valve Replacement Surgery. JOURNAL OF CLINICAL RESEARCH, 2017, 34(8): 1501-1503,1507.
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2017, Vol. 34 
