Abstract：【Objective】To investigate the effect of voriconazole in the treatment of chronic renal insufficiency(CRF) with pulmonary fungal infection(PFI).【Methods】A total of 82 CRF patients with PFI were divided into two groups , with 41 cases in each group. The control group and experimental group were each treated with fluconazole and voriconazole, respectively. The clinical efficacy, vital signs, renal function [blood urea nitrogen (BUN), creatinine clearance rate (Ccr), 24h urine protein quantitation], drug safety and the recurrence rate after one year after treatment were observed in both groups.【Results】After treatment, the total effective rate was 87.80% (36/41) in the experimental group, which was significantly higher than that in the control group 68.29% (28/41). The incidence rate of adverse reactions and one-year recurrence rate in the experimental group were lower than those in the control group (P＜0.05).Before treatment, there were no significant differences in vital signs and renal function between the two groups (P＞0.05). After treatment, body temperature, pulse, respiration, systolic blood pressure, diastolic blood pressure, BUN, and 24h urinary protein quantitation were significantly decreased in both groups, while Ccr was significantly increased. However, the change in these indicators in the experimental group was more significant than that in the control group (P＜0.05).【Conclusion】Voriconazole is more effective in the treatment of CRF with PFI and it shows a safer and lower recurrence rate as well. It is worthy of promotion in clinical application.
张平. 伏立康唑治疗慢性肾功能不全合并肺部真菌感染的疗效[J]. 医学临床研究, 2017, 34(8): 1487-1488,1491.
ZHANG Ping. Efficacy of Voriconazole in the Treatment of Chronic Renal Insufficiency with Pulmonary Fungal Infection. JOURNAL OF CLINICAL RESEARCH, 2017, 34(8): 1487-1488,1491.
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2017, Vol. 34 
