Abstract：【Objective】To investigate the effect and feasibility of dexmedetomidine combined with sufentanil in sedation during the daytime surgery in the department of general surgery.【Methods】Six-four cases of patients undergoing daytime surgery were randomly divided into two groups by random, 32 cases in each group. Dexmedetomidine group (group A) received dexmedetomidine 0.3 g/kg before operation, and sufentanil 0.1g/kg 10min after intravenous injection. Dexmedetomidine was pumped between 0.2 and 0.4 g/kg min in operation to maintain anesthesia; Propofol group (group B) received sufentanil 0.1 g/kg + propofol 1.5mg/kg, intraoperative pumpe propofol 3~61.5 mg/(kg·h) for anesthesia maintenance. The operation of the two groups was compared, and the changes of mean arterial pressure point (MAP) , heart rate (HR), oxygen saturation (SpO2), OAA/S score at time points such as pre-operation (T0), the beginning of the operation (T1), 10min surgery (T2), 60min surgery (T3) and a chamber (T4) were recorded.【Results】The recovery time and length of stay in recovery room of the group A were shorter than those of the group B, and the difference was significant (P＜0.05). T1~T3, MAP, SpO2 and OAA/S score of the group A were higher than those of the group B (P＜0.05). There was no significant difference in HR between the two groups at different time points (P＞0.05). There was no significant difference in operation memory between the two groups (P＞0.05); The incidence rates of hypotension, lethargy and respiratory depression in the dexmedetomidine group were lower than those in the propofol group (P＜0.05). 【Conclusion】Compared with propofol, the combination of dexmedetomidine and sufentanil for sedation during daytime surgery in the department of general surgery has more advantages in shortening postoperative wake time, maintaining hemodynamic stability and reducing adverse reactions. Although the effect of adaptive forgetting effect is relatively low, it will not affect the normal operation.
2017, Vol. 34 
