Abstract：【Objective】To investigate the effect of subclinical hypothyroidism (SCH) and gestational hypertension on maternal and neonatal outcomes. 【Methods】 A total of 90 patients with gestational SCH treated in the hospital from May 2014 to March 2016 and 40 healthy volunteers (the healthy group) who received antenatal care in the same period were selected as subjects. According to the blood pressure measured after 25~28 weeks of pregnancy, the patients with gestational SCH were divided into the combined group (48 cases of SCH with gestational hypertension) and the control group (42 cases of SCH without hypertension). The thyroid function [thyroid stimulating hormone (TSH), free thyroxine (FT4), thyroid peroxidase antibody (TPO-Ab)], blood lipid levels [triglyceride (TG), serum total cholesterol (TC), low-density lipoprotein (LDLC)], maternal and neonatal outcomes, and the incidence of pregnancy complications were compared among the three groups. 【Results】 The levels of TSH and TPO-Ab in the combined group were significantly higher than those in both the control group and the healthy group, while FT4 was lower. The levels of TG, TC and LDLC were the highest in the combined group and followed by the control group, and those in the healthy group were the lowest. There were significant differences between any two groups (P＜0.05). The total incidence of adverse maternal and neonatal outcomes, and pregnancy complications in the combined group were the highest (47.92%, 31.25%), followed by the control group (16.67%, 11.90%), and the incidence was lowest in the healthy group (2.50%, 0.00%). There were significant differences between any two groups (P＜0.05). 【Conclusion】 SCH is closely related to pregnancy-induced hypertension, which may be related to abnormal lipid metabolism. The total incidence of adverse maternal and neonatal outcomes in patients with SCH complicated with pregnancy-induced hypertension is significantly higher than that in pregnant women with single disease or healthy pregnant women.
2017, Vol. 34 
