Abstract：【Objective】To explore the effect of propofol applied in LC on cardiac function, IR and levels of inflammatory factors in patients of cholecystitis complicated with T2DM. 【Methods】One hundred and four patients of cholecystitis complicated with T2DM treated by LC were randomized into study group(A) and control group(B), 52 in each group. The group A was treated with propofol while the group B was treated with isoflurane maintenance anesthesia. The changes of hemodynamic parameters MAP, HR were compared between the two groups before anesthesia (T 0), after anesthesia (T 1), 5min after establishment of pneumoperitoneum (T 2) and immediate after the surgery (T 3). The differences in IR index, inflammatory factors TNF-α, CRP and myocardial function indexes CK-MB, cTnI before and after treatment were recorded, and postoperative recovery was analyzed.【Results】① At T 1 , MAP and HR of both groups were significantly lower than those at T 0 (P＜0.05) but there were no significant differences between groups at different time points (P＞0.05). ②After surgery, IR and levels of TNF-α, CRP were significantly higher than those before operation, and those in the group A were higher than those of the group B (P＜0.05). There were no significant changes of CK-MB and cTnI in group A, compared with those before operation (P＞0.05) while those in group B were significantly higher than those before operation (P＜0.05). ③The time of spontaneous breathing recovery, duration of eye opening, extubation time and time of directive force recovery in the group A were significantly shorter than those of the group B (P＜0.05). 【Conclusion】 The application of propofol combined with fentanyl anesthesia in LC of patients with cholecystitis complicated with T2DM mellitus is of positive significance in improving the state of IR, regulating the surgical trauma stress response and protecting cardiovascular system.
杨洪胜,陈伟,苏瑶. 丙泊酚对伴2型糖尿病胆囊炎行LC患者心肌功能和IR及炎症因子水平的影响[J]. 医学临床研究, 2017, 34(7): 1310-1312.
YANG Hong-shen, CHEN Wei, SHU Yao. Effect of Propofol Applied in LC on Cardiac Function, IR and Levels of Inflammatory Factors in Patients of Cholecystitis Complicated with T2DM. JOURNAL OF CLINICAL RESEARCH, 2017, 34(7): 1310-1312.
2017, Vol. 34 
