Abstract：【Objective】The aim was to investigate the correlation among serum factors such as hypoxia-inducible factor-1α (HIF-1α), cystatin C (Cys C) and β2-microglobulin (β2-MG) with early renal injury in elderly patients with chronic obstructive pulmonary disease (COPD). 【Methods】A total of 95 elderly patients with COPD in our hospital from January 2012 to January 2016 were enrolled. They were divided into three groups:mild, moderate and severe hypoxia (A1, A2, and A3) according to oxygen partial pressure (PaO2). Based on pulmonary artery systolic pressure, patients were split into two groups B1 (without pulmonary hypertension) and B2 (pulmonary hypertension) . Thirty cases of healthy persons in the same period were selected as the control group. HIF-1α, Cys C, and β2-MG levels in serum were detected by ELISA. The renal function index (SCr, BUN,RBP and eGFR) were measured as well. The changes of the indexes were compared and analyzed. 【Results】The levels of HIF-1α, Cys C and β2-MG in serum were higher in COPD group than that in healthy control group (P＜0.05); eGFR was lower than that of the control group (P＜0.05). SCr, BUN and RBP had no significant difference between COPD group and control group. The levels of HIF-1α, Cys C and β2-MG in the control group were significantly lower than those in the A1 group, while those in the A1 group were lower than those in the A2 group (P＜0.05) and those in the A2 group were lower than those in the A3 group. The eGFR in the A2 and A3 groups were lower than that in the control group (P＜0.05). There was no significant difference in eGFR between the A1 group and the control group (P＞0.05). The levels of HIF-1α, Cys C and β2-MG were in order of control group ＜ group B1＜ group B2 (P＜0.05), and eGFR in the B2 group was lower than in the control group (P＜0.05). HIF-1α, β2-MG and Cys C were positively correlated (r= 0.563,r=0.425, P＜0.05), HIF-1α, Cys C, β2-MG and eGFR were negatively correlated (r=-0.611,r=-0.569,r=-0.482,P＜0.05). 【Conclusion】The results show that chronic hypoxia in COPD can cause early renal injury. Monitoring HIF-1α, Cys C and β2-MG levels in serum can be used to evaluate early renal injury in COPD patients. Combined detection may be important for early renal injury assessment in COPD patients.
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2017, Vol. 34 
