Abstract：【Objective】The aim was to investigate the levels of serum CRP, FT3, and TNF-α level in patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD) for assessment of its severity. 【Methods】A total of 106 patients with AECOPD from October 2012 to October 2015 in our hospital were selected: 48 patients with respiratory failure were chosen to be in Group A and 58 patients without respiratory failure in Group B. Meanwhile, 30 patients without AECOPD were selected as Group C. Serum level of CRP was determined by immunoturbidimetry, FT3 was measured by chemiluminescent method, and TNF-α was measured by enzyme-linked immunosorbent assay (ELISA). The correlation between severity of disease and serum levels of CRP, FT3, and TNF-α was analyzed. 【Results】The serum levels of CRP and TNF-α showed the order of Group A >Group B > Group C (P<0.05). The serum levels of FT3, however, showed the reverse order with Group A < Group B < Group C (P<0.05). After treatment, the levels of CRP and TNF-α in patients with AECOPD were significantly lower than those before treatment (P<0.05), while the levels of FT3 were significantly higher than that before treatment (P <0.05). Before treatment, the abnormal rate of CRP was higher than the abnormal rate of WBC and the abnormal rate of neutrophils (N%) (P<0.05). 【Conclusion】The results show that serum levels of CRP, TNF-α, and FT3 are correlated with the severity of AECOPD, and could be used as reference indices for the severity of AECOPD.
刘彦坡. 慢阻肺急性加重期患者血清CRP、FT3、TNF-α测定在病情严重程度评估中的意义[J]. 医学临床研究, 2017, 34(6): 1109-1111.
LIU Yan-po. Levels of Serum CRP, FT3, and TNF-α in the Severity Assessment of Patients with Acute Exacerbation of Chronic Obstructive Pulmonary Disease. JOURNAL OF CLINICAL RESEARCH, 2017, 34(6): 1109-1111.
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2017, Vol. 34 
