Abstract：【Objective】To investigate the effect of Magnesium Sulfate injection by duodenal scope on serum amylase level and the occurrence of pancreatitis in patients undergoing endoscopic retrograde cholangiopancreatography(ERCP).【Methods】A total of 82 patients undergoing ERCP in our hospital from May 2014 to May 2016 were enrolled in the study. Patients were randomly divided into magnesium sulfate group and routine group by random number table method, 41 cases in each group. All patients were treated by ERCP, endoscopic sphincteropapillotomy and endoscopic stone removal. Before intubation, magnesium sulfate was sprayed locally on duodenal papilla in magnesium sulfate group. Serum amylase, C reactive protein (CRP), Oddi sphincter pressure, success rate of intubation and incidence of complications were compared between the two groups. 【Results】The serum amylase and CRP levels of the two groups after 6 h and 24 h were significantly higher than those before the operation, and the difference was statistically significant (P<0.05); The levels of serum amylase and CRP in the Magnesium Sulfate group after 6 h and 24 h were significantly lower than those in the conventional group (P<0.05). 10 min after spraying, the SO basal pressure, SO contraction amplitude and SO contraction frequency of the two groups were significantly higher than those before spraying (P<0.05). There was no significant difference in SO interval between the Magnesium Sulfate group and the normal group after 10 min spraying (P>0.05); The SO basal pressure, SO contraction amplitude and SO contraction frequency were significantly lower than those in the conventional group (P<0.05). The successful rate of intubation in Magnesium Sulfate group was significantly higher than that in routine group, the incidence of pancreatitis and amylase was significantly lower than that of the routine group, the difference was statistically significant (P<0.05).【Conclusion】 In ERCP surgery, Magnesium Sulfate injection can relax the sphincter of Oddi by endoscopy ,which can improve the success rate of intubation, reduce the damage of pancreatic tissue, reduce the level of serum amylase and the incidence of pancreatitis.
王艳静,许丙辉,台剑熊,齐双玉,刘昭明,樊晓意,李恒力. ERCP术中经十二指肠镜注入硫酸镁对胆总管结石患者血清淀粉酶水平的影响[J]. 医学临床研究, 2017, 34(6): 1102-1105.
WANG Yan-jing, XU Bing-hui, TAI Jian-xiong,et al. Effect of Magnesium Sulfate Injection under Duodenoscope on Pancreatitis and Serum Amylase Level in ERCP. JOURNAL OF CLINICAL RESEARCH, 2017, 34(6): 1102-1105.
2017, Vol. 34 
