Effects of Oxycodone Combined with Dexmedetomidine on Intraoperative Respiratory and Circulatory Function in Patients Undergoing Awake Tracheal Intubation
FENG Nian-hai, ZHANG Lu, LI Xiao-min, et al
Department of anesthesia, Central Hospital of ZiBo,Zibo Shandong 255036
Abstract：【Objective】To study the effects of oxycodone combined with dexmedetomidine on intraoperative respiratory and circulatory functions in patients undergoing awake tracheal intubation. 【Methods】Eighty-two patients who received elective operation for difficult airway were divided into two groups with 41 cases in each group. The control group was given sufentanil combined with dexmedetomidine anesthesia, while the observation group was given oxycodone combined with dexmedetomidine anesthesia. The changes of circulatory system parameters and respiratory function indices were compared between the two groups at different time points. The sedation score (Ramsay) before intubation, comfort score after intubation, and the incidence of adverse reactions were compared between the two groups. 【Results】The levels of SBP, DBP, MAP, and HR in the observation group were significantly higher than those in the control group at 1 min and 5 min after induction (P<0.05). The level of MAP was significantly higher than that in the control group 1 min after intubation (P<0.05). At 3 min after intubation and at the time of intubation removal, the levels of PAW and PETCO2 in the control group were higher than those in the observation group (P<0.05). The total incidence of adverse reactions in the observation group, 9.76%, was significantly lower than that in the control group ,29.27% (P<0.05). 【Conclusion】The application of oxycodone combined with dexmedetomidine is safe in patients undergoing awake tracheal intubation. Its analgesic and sedative effects are good. It has little effect on respiratory function and circulatory function and has a low incidence of adverse reactions.
冯念海,张璐,李晓敏,张玉柱,张洪勤. 羟考酮复合右美托咪定对清醒气管插管患者术中呼吸及循环功能的影响[J]. 医学临床研究, 2017, 34(6): 1090-1092.
FENG Nian-hai, ZHANG Lu, LI Xiao-min, et al. Effects of Oxycodone Combined with Dexmedetomidine on Intraoperative Respiratory and Circulatory Function in Patients Undergoing Awake Tracheal Intubation. JOURNAL OF CLINICAL RESEARCH, 2017, 34(6): 1090-1092.
2017, Vol. 34 
