Abstract：【Objective】To investigate the expression and significance of serum Vaspin and CTRP9 levels in patients with polycystic ovary syndrome. 【Methods】 Fifty-nine cases diagnosed PCOS patients from March 2015 to August 2016 in our hospital (observation group) were selected, according to the body mass index [(BMI) WHO obese than 25kg/m2] they wee divided into non obese group A (28 cases), obesity group B (31 cases ); In addition, 60 healthy women (control group) who underwent physical examination in our hospital were divided into non obese 31 cases (control group A) and obesity 29 cases (control group B) according to BMI. Detection and comparison of four groups of patients with serum Vaspin, CTRP9 levels were compared between the four groups in general and biochemical indicators such as three triglycerides (TG), total cholesterol (TC), high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C), fasting insulin resistance index (FINS), total testosterone and insulin (HOMA-IR), and the level of steady period of 120 to 180 min glucose metabolic rate (M120-180).【Results】 The serum Vaspin level of the observation group was significantly higher than that of the control group, and the serum CTRP9 level was significantly lower than that of the control group, the difference was statistically significant (P<0.05); Pearson correlation analysis showed that the level of Vaspin was negatively correlated with HDL-C and M120-180 (P<0.05), and positively correlated with BMI, TC, LDL-C, waist circumference, FINS, TG, total testosterone, and HOMA-IR levels (P<0.05); The level of CTRP9 was positively correlated with HDL-C and M120-180 (P<0.05), and negatively correlated with BMI, TC, LDL-C, waist circumference, FINS, TG, total testosterone and HOMA-IR levels (P<0.05); Serum levels of Vaspin and CTRP9 were not significantly correlated with age (P>0.05). 【Conclusion】 Compared with the healthy population, PCOS patients have higher serum Vaspin levels and lower CTRP9 levels; The indexes of BMI, TC, HDL-C, waist circumference, FINS, TG, total testosterone, HOMA-IR, LDL-C and M120-180 were closely related to serum levels of Vaspin and CTRP9.
王玉红,张忠强,卢静. 血清Vaspin、CTRP9在多囊卵巢综合征患者中的表达及其意义[J]. 医学临床研究, 2017, 34(6): 1081-1084,1086.
WANG Yu-hong, ZHANG Zhon-qiang, LU Jing. Expression and Significance of Serum Vaspin and CTRP9 Levels in Patients with Polycystic Ovary Syndrome. JOURNAL OF CLINICAL RESEARCH, 2017, 34(6): 1081-1084,1086.
[1] 张杰,张翔,延静,等. 肥胖和非肥胖多囊卵巢综合征患者的临床特征[J]. 医学临床研究,2017,34(3):456-458. [2] 张琳,李敬 ,王泽,等.多囊卵巢综合征患者促甲状腺激素对血糖、血脂的影响[J].山东大学学报(医学版) ,2017,55(1):80-84. [3] 丁春丽,侯丽辉,郝松莉,等.多囊卵巢综合征患者中医体质与性激素、脂代谢的相关性分析[J].中医杂志,2016,57(15):1303-1307. [4] Gower BA , Goss AM.A lower-carbohydrate, higher-fat diet reduces abdominal and intermuscular fat and increases insulin sensitivity in adults at risk of type 2 diabetes[J]. J Nutr,2015,145(1):177S-83S. [5] 梁琳.多囊卵巢综合征发生的危险因素及运动减脂干预措施对其影响的研究进展[J].中华妇幼临床医学杂志(电子版) ,2016,12(3):354-359.
[6] Rotterdam ESHRE/ASRM-Sponsored PCOS Consensus Workshop Group.Revised 2003 consensus diagnostic criteria and long-term health risks related to polycystic ovary syndrome[J]. Fertil Steril,2004,81(1):19-25. [7] 胡婷.多囊卵巢综合征的病因研究进展[J].中华妇幼临床医学杂志(电子版),2016,12(3):360-363. [8] 张杰,张翔,延静,等. 多囊卵巢综合征超声影像特征及与性激素、胰岛素抵抗指数的相关性分析[J]. 医学临床研究,2017,34(3):456-458. [9] 王雪,张翠莲,张少娣,等.体质量指数对多囊卵巢综合征患者移植优质胚胎后早期妊娠丢失的影响[J].实用妇产科杂志,2016,32(3):220-224. [10] 贺飞,陈文信,李红,等.肥胖与多囊卵巢综合征的关系探讨及肥胖型多囊卵巢综合征治疗的研究进展[J].河北中医,2016,38(09):1422-1426,1431. [11] Mazaki-Tovi S , Vaisbuch E , Tarca AL, et al. Characterization of visceral and subcutaneous adipose tissue transcriptome and biological pathways in pregnant and non-pregnant women: evidence for pregnancy-related regional-specific differences in adipose tissue[J].PLoS One,2015,10(12): e0143779. [12] 王丽,林翔东,倪桂莲,等.急性脑梗死患者血清Vaspin Omentin-1水平及其临床意义[J].浙江临床医学,2016,18(3):415-417. [13] 王明明,刘师伟,杜芳,等.Vaspin对糖尿病肾病大鼠肾脏保护作用的研究[J].中国中西医结合肾病杂志,2016,17(8):675-677. [14] Marcher AB , Loft A , Nielsen R, et al. RNA-seq and mass-spectrometry-based lipidomics reveal extensive changes of glycerolipid pathways in brown adipose tissue in response to cold[J]. Cell Rep,2015,13(9):2000-2013. [15] 金婷,宋荣蓉,韩亚 ,等.急性脑卒中患者血清瘦素/脂联素比值与认知损害的关系 [J].中国急救医学,2017,37(1):65-68. [16] 张敏,吴晨光,陈小罗,等.肥胖及初诊2型糖尿病患者血清C1补体肿瘤坏死因子相关蛋白12水平变化及相关因素分析[J].中华糖尿病杂志,2016,8(12):763-766. (本文编辑:邓丽萍) [收稿日期] 2017-04-01
2017, Vol. 34 
