Abstract：【Objective】To investigate the effects of Magnolia (Magnolol, Mag) that inhibited the biological activity of different breast cancer cell lines in vitro. 【Methods】 Human breast cancer high metastatic cell lines MCF-7 and MDA-MB-231 were used in the study. Different concentrations of Mag solution were added to the culture medium to observe the rate of apoptosis, invasion, migration and adhesion capacity. Then, the effects of Mag on biological activity of breast cancer cell line were evaluated. 【Results】Data showed that Mag inhibited the rate of apoptosis, invasion, metastasis and adhesion ability in two breast cancer cell lines (P<0.05), and that with the increase of Mag concentration, the inhibitory activity on the biological activity was increased (P<0.05). 【Conclusion】Mag can inhibit the biological activities of breast cancer cell lines by inhibiting the apoptotic rate, the ability of invasion, and the adhesion and migration of breast cancer cell lines.It has an important value in the treatment and prevention of breast cancer recurrence or metastasis in clinic.
黄自明,姜冉,魏刚,田亦文,卢文亮,高丹,陈波,叶春梅,薛明兴,王蓉. 厚朴酚抑制体外乳腺癌细胞株生物活性的实验研究[J]. 医学临床研究, 2017, 34(6): 1047-1050.
HUANG Zi-ming, JIANG Ran, WEI Gang,et al. Experimental Study on the Inhibition of Magnolol on Biological Activities of Human Breast Cancer Cell Lines in Vitro. JOURNAL OF CLINICAL RESEARCH, 2017, 34(6): 1047-1050.
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2017, Vol. 34 
