Abstract： Objective To investigate the effect of general anesthesia combined with regional nerve block on stress response, inflammatory response and analgesic effect in patients with malignant gastrointestinal tumors after laparoscopic operation. Methods Ninety patients with malignant gastrointestinal tumors were randomly divided into A, B and C groups, 30 cases in each group. The Group A was treated with intravenous anesthesia, the Group B received general anesthesia combined with epidural anesthesia, and the Group C underwent general anesthesia combined with transversus abdominis plane block. Comparison of three groups were made on anesthesia, skin incision of three groups (T0), 5min after skin incision (T1) and the mean arterial pressure (MAP) at the end of operation (T2), heart rate (HR), intra/postoperative cortisol (Cor) and inflammatory factors (IL-6, tumor necrosis factors) levels, postoperative pain and complications. Results The hospitalization time and lying in bed time of the three groups were the Group C>the Group B and the Group A (P<0.05); the increase of MAP and HR in T0~T2 time range was smaller than that in group A (P<0.05); after operation ,the Cor, IL-6, TNF-αof the Group C increased significantly compared with the Group B and the Group A (P<0.05); 6h, 12h after operation, VAS were less than that of the Group A and the Group B (P<0.05); complication rate of the Group C was 3.33%, significantly lower than that in the Group A 23.33% and the Group B 20% (P<0.05). Conclusion General anesthesia combined with regional nerve block can obviously reduce the stress response, inflammatory response, pain with less dosage of anesthetics in patients with malignant gastrointestinal tumors.
沈学用,谢少杰,陈仁军. 全麻联合区域神经阻滞对结直肠癌腹腔镜手术患者应激反应及镇痛效果的影响[J]. 医学临床研究, 2017, 34(5): 906-909.
SHEN Xue-yong, XIE Shao-jie, CHEN Ren-jun. Effect of General Anesthesia Combined with Regional Nerve Block on Stress Response in Patients with Colorectal Cancer Surgery and Analgesia. JOURNAL OF CLINICAL RESEARCH, 2017, 34(5): 906-909.
2017, Vol. 34 
