Value of Serum Procalcitonin, Lactic Acid and Brain Natriuretic Peptide in the Diagnosis and Prognosis of Elderly Patients with Community-acquired Pneumonia
ZHAUG Zhi, ZHU Can-hong, LI Rong, et al
The Department of Geriatric Medicine, Zhenjiang First People‘s Hospital, Zhenjiang Jiangsu, 212002
Abstract： Objective To evaluate the value of serum procalcitonin (PCT), lactic acid (LA) and brain natriuretic peptide (BNP) in the diagnosis and prognosis of community-acquired pneumonia. Methods From May 2015 to July 2016, 82 elderly patients with community-acquired pneumonia were enrolled in this study as the pneumonia group. Eighty healthy volunteers were selected as the control group. Serum levels of procalcitonin, lactate and BNP were measured in two groups. Results The levels of plasma procalcitonin (0.99 ± 0.42) μg/L, lactic acid (3.90±1.09) mmol/L and BNP (159.26±19.80) pg/ml in pneumonia group were significantly higher than those in control group, (0.17±0.31) μg/L , (0.92±0.33) mmol/L and (50.01 ±13.40) pg/ml, respectively. There were significant differences between the two groups (P<0.05). Of the 82 patients with pneumonia, 10 (12.20%) died. The levels of procalcitonin (1.85±0.47) μg / L, lactate (6.20±1.21) mmol/L and BNP (278.78±25.80) pg/mL in the death group were significantly higher than those in the survivors group, (0.87±0.39) (3.58±0.98) mmol/L and (142.66±17.46) pg/ml, respectively. The difference was significant (P<0.05). ROC analysis showed that the sensitivity and specificity of the detection order was: calcitonin>lactate> BNP. Combination of calcitonin,lactate,and BNP was higher than single index (P<0.05). Conclusion The levels of serum procalcitonin, lactate and BNP are closely related to the development and prognosis of community-acquired pneumonia in elderly patients. Combined use of these three indexes can further improve the application value.
庄志,朱灿宏,李蓉,林英. 血清降钙素原、乳酸和脑钠肽在老年社区获得性肺炎诊断和预后评估中的价值[J]. 医学临床研究, 2017, 34(5): 898-900.
ZHAUG Zhi, ZHU Can-hong, LI Rong, et al. Value of Serum Procalcitonin, Lactic Acid and Brain Natriuretic Peptide in the Diagnosis and Prognosis of Elderly Patients with Community-acquired Pneumonia. JOURNAL OF CLINICAL RESEARCH, 2017, 34(5): 898-900.
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2017, Vol. 34 
