Abstract： Objective To analyze the correlation between non-receptor protein tyrosine phosphatase 22 (PTPN22) gene polymorphism and the susceptibility of idiopathic thrombocytopenic purpura (ITP) in children. Methods Gene polymorphism of PTPN22-1123G>C (rs2488457) in 120 children with ITP (the observation group) and 80 normal children (the control group) was determined by PCR-MALDI-TOF MS method. Results The C frequency of PTPN22-1123G > C allele in the observation group was 62.50% ,which was significantly lower than that in the control group (71.25%) (P<0.05), while there were no significant differences in genotypes between the two groups (P>0.05). The allele frequency showed significant differences in boys in the two groups (P<0.05), while there were no significant differences in girls (P>0.05). There were no significant differences in genotypes in children with the same gender (P>0.05). Conclusion The PTPN22-1123G>C polymorphism is associated with susceptibility of ITP in children. C is the dominant allele while G is the risk allele. The allele frequencies of PTPN22-1123G > C may be related to the gender of children.
李方方,李天宇,徐大明,张茜. PTPN22基因多态性与儿童血小板减少性紫癜易感性的关联分析[J]. 医学临床研究, 2017, 34(5): 889-892.
LI Fang-fang, LI Tian-yu, XU Da-ming,et al. Correlation Between PTPN22 Gene Polymorphism and Susceptibility of Idiopathic Thrombocytopenic Purpura in Children. JOURNAL OF CLINICAL RESEARCH, 2017, 34(5): 889-892.
2017, Vol. 34 
