Abstract： Objective To explore the correlation between fractional exhaled nitric oxide (FeNO) , blood eosinophilic granulocyte (Eos)and Eos% with serum total immunoglobulin E (TIgE) in patients with bronchial asthma. Methods Eighty bronchial asthma patients hospitalized in our hospital from October, 2014 to September,2015 were selected as the observation group; meanwhile, 80 check-up volunteers in the above-mentioned hospital were selected randomly as the control group. Exhaled FeNO, blood Eos, Eos% and TIgE levels were compared between the two groups to analyze the correlation between FeNO levels and other indicators. Results The level of FeNO in the observation group (51.48±13.09) was significantly higher than that of the control group(11.29±4.37)ppb, while the score of ACT in the observation group (15.39±3.21) was significantly lower than that of the control group(23.64±4.29), with statistically significant differences between the two groups( P<0.05). The levels of Eos, Eos% and TIgE in the observation group were (264.28±32.19)×106/L,(6.39±1.21)% and(134.38±19.73)kU/L respectively, which were all significantly higher than those of the control group [(67.49±9.74) ×106/L、(1.21±0.59)%、(92.10±11.49)kU/L](P＜0.05). Regression analysis showed that the level of FeNO did not correlated with the level of TIgE (P>0.05), and positively correlated with Eos count and Eos% level (P<0.05). Conclusions As a noninvasive examination, the test results FeNO detection can directly reflect the situation of chronic airway inflammation of allergic asthma patients, especially in the inflammatory response of Eos, and it is also conducive to accurately evaluate the severity of allergic asthma. Therefore, it is worthy of clinical application.
刘念,罗红,刘志光. 支气管哮喘患者呼出气一氧化氮与血嗜酸性粒细胞数量及比例和免疫球蛋白E的相关性分析[J]. 医学临床研究, 2017, 34(5): 879-882,885.
LIU Nian, LUO Hong, LIU Zhi-guang. Correlation between Fractional Exhaled Nitric oxide (FeNO) and Blood Eos, Eos%, Serum TIgE in Patients with Bronchial Asthma. JOURNAL OF CLINICAL RESEARCH, 2017, 34(5): 879-882,885.
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