Abstract： Objective To study on the efficiency of methionine and vitaminB1 in the treatment of hepatic cirrhosis and their effects on liver function, symptoms and complications . Methods From March 2013 to March 2016, there were 80 patients with hepatocirrhosis treated in our hospital. Their clinical data were analyzed retrospectively. Among them, 38 patients were treated by the traditional method (the control group). On the basis of traditional method, 42 patients received Methionine and VitaminB1 treatment (the experimental group). The effects of these treatments were observed and compared between the two groups. Results (1) Before treatment, there were no significant differences in liver function (i.e. TBIL, ALT, CHE, FN) and serum liver fibrosis (HA、PCⅢ、LN、cⅣ) between the experimental and controls (P<0.05). After treatment, the indicators stated above in the experimental group were significantly lower than those in the control group (P<0.05); (2) The total effective rate of the experimental group was higher than that of the control group (85.71% VS 71.05%) (P<0.05); (3) The incidence of complications (liver and kidney syndrome, hepatic encephalopathy, spontaneous bacterial peritonitis) in the experimental group was significantly lower than that in the control group (9.52% VS 26.32%) (P<0.05). Conclusion Methionine and VitaminB1 can significantly improve the liver function and symptoms. The treatment is safe and effective. Therefore, this method is worthy of further promotion and use in clinic.
张雪芹,王茜. 甲硫氨酸维B1治疗肝硬化的临床效果及对患者肝功能指标的影响[J]. 医学临床研究, 2017, 34(5): 869-871.
ZHANG Xue-qin,WANG Qian. Study on Efficacy of Methionine and Vitamin B1 in the treatment of Liver Cirrhosis. JOURNAL OF CLINICAL RESEARCH, 2017, 34(5): 869-871.
2017, Vol. 34 
