Abstract： Objective To investigate the prognostic value of serum interleukin-18 with NIHSS (National Institutes of Health Stroke Scale) and mRS (modified Rankin scale) in patients with actual cerebral infarction (ACI). Methods A total of 100 cases of ACI patients from August 2013 to December 2014 in our hospital were chosen as the subjects of the study.All were diagnosed as ACI by head CT or MRI based on the guidelines of China Ischemic Stroke Treatmentin 2010. According to the score of NIHSS, patients were divided into mild group(NIHSS score<7), moderately severe group (NIHSS score 7～15) and severe group (NIHSS scor >15).At same time period, sixty healthy volunteers were collected as control.Serum interleukin-18 levels were measured within 24hamong all patients in ACI and control group. The relevance and relationship between serum interleukin-18 levels and Alberta CT (ASPECT) scores plus NIHSS scores were analyzed. All patients were followed up on the day of 90 and 180; neurological impairment was assessed by mRS score; the correlation between plasma interleukin-18 levels and prognosis were analyzed. Results Patients'serum interleukin-18 levels 24h after hospitalization were significantly higher than that in the healthy control group (P<0.05). The interleukin-18 levels were (526.36±26.82)ng/L,(439.24±26.45)ng/L,and (385±34.26)ng/L,respectively, in severe group, moderate severe group and mild group. The differences among the three groups were statistically significant (P<0.05). Interleukin-18 level in the poor prognosis group was significantly higher than the good prognosis group(P<0.05). Serum interleukin-18 levels were positively correlated betweenwith ASPECT scores and NIHSS scores. Univariate Logistic regression analysis showed that the age, ASPECT score, NIHSS score, and interleukin-18 levels were prognostic factors of ACI patients (P<0.05). Area under the receiver's work curve (ROC) analysis showed that the predictive value of serum interleukin-18 was no significant difference with NIHSS score and ASPECT score in predicting outcomes of ACIpatients . Conclusion Plasma interleukin-18 levels were significantly elevated in patients with acute ACI; there is a significant positive correlation between serum interleukin-18 levels within 24 hours with neurologic impairment severity and prognosis in ACI patients. Serum interleukin-18 levels has great value in assessing the severity and prognosis in patients with ACI.
赵焱,陈向东,张艳梅,冯银玲,马翔凌. IL-18联合NIHSS、mRS评分对ACI患者预后的预测价值[J]. 医学临床研究, 2017, 34(5): 857-860.
ZHAO Yan, CHEN Xiang-dong, ZHANG Yan-mei,et al. Prognostic Value of Interleukin-18 with NIHSS and mRS Scores in Patients with Acute Cerebral Infarction. JOURNAL OF CLINICAL RESEARCH, 2017, 34(5): 857-860.
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