Abstract： Objective To investigate the expression of solube receptor for advanced glycation end products (sRAGE) in patients with polycystic ovary syndrome (PCOS) and its clinical significance. Methods From January 2015 to April 2016, 80 patients with PCOS were enrolled in the reproductive center of our hospital. PCOS patients were divided into four groups according to whether or not accompanied by hyperandrogenism / insulin resistance (IR). Group A: PCOS+ without NHA + without high insulin resistance (NIR); Group B: PCOS+IR; Group C: PCOS+HA; Group D: PCOS+HA+IR, 20 cases in each group. 20 healthy women were selected as the normal control group (group E). The levels of luteinizing hormone (LH), testosterone (T) and fasting insulin (FINS) were detected by electrochemiluminescence assay, Fasting serum glucose (fasting, blood, glucose, FBG) and ELISA were used to detect serum sRAGE levels by sugar kinase method; the degree of IR was evaluated by HOMA-IR. The correlation between sRAGE and indexes was analyzed. Results sRAGE value from high to the bottom were group E, group A, group C, group B, group D (P<0.05), the difference between the two groups was statistically significant (P<0.05); sRAGE was negatively related to LH, T, FBG, FINS and HOME-IR. Conclusion sRAGE can combine with the ligand of RAGE competitively , weaken the pathological role caused, has potential protective effect in PCOS.
刘丽丽. 可溶性晚期糖基化终末产物受体在多囊卵巢综合征中的表达及其意义[J]. 医学临床研究, 2017, 34(5): 850-853,856.
LIU Li-li. Expression of Soluble Advanced Glycosylatio End Product Receptor and its Significance in Patents with Polycystic Ovary Syndrome. JOURNAL OF CLINICAL RESEARCH, 2017, 34(5): 850-853,856.
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