Abstract：【Objective】To investigate the clinical effects of atorvastatin in the treatment of diabetic patients with hypertension and its effects on levels of urine β2 microglobulin (β2-MG), serum creatinine (Scr) and glycosylated hemoglobin (HbA1c). 【Methods】Eighty-six patients with diabetes and hypertension were randomly divided into the control group and the observation group, with 43 cases in each group. The control group was given conventional symptomatic treatment, while the observation group was additionally treated with atorvastatin. The therapeutic effects were compared between the two groups. The changes of levels of urine β2-MG, Scr, HbA1c, total cholesterol (TC), triacylglycerol (TG), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), high-sensitivity C reactive protein (hs-CRP), and interleukin -6 (IL-6) before and after treatment were determined; the incidence of adverse reactions was statistically analyzed. 【Results】 The total effective rate was 95.35% (41/43) in the observation group, which was higher than that in the control group (79.70%, 34/43); the difference was statistically significant (χ2=5.107,P=0.023). Before treatment, the indexes showed no significant differences between the two groups (P>0.05). After treatment, the levels of β2-MG, Scr, HbA1c, TC, LDL-C, IL-6, and hs-CRP decreased P<0.05)-the decrease in the observation group was greater than that in the control group (all P<0.05). 【Conclusion】 Atorvastatin is effective in the treatment of diabetic patients with hypertension. It can reduce the levels of blood lipids and inflammatory factors as well as improve renal function.
江丽华;韩晓骏;苏如婷;. 阿托伐他汀治疗糖尿病伴高血压患者的疗效及对尿β2-MG、SCr、HbAlc水平的影响[J]. 医学临床研究, 2017, 34(4): 628-631,634.
JIANG Li-hua, HAN Xiao-jun, SU Ru-ting. Clinical Efficacy of Atorvastatin on Diabetic Patients with Hypertension and its Effects on Urinary β2-MG, SCr and HbAlc Levels. JOURNAL OF CLINICAL RESEARCH, 2017, 34(4): 628-631,634.
2017, Vol. 34 
