Abstract：【Objective】To investigate the application of dezocine and sufentanil combined with different doses of dexmedetomidine in abdominal hysterectomy surgery. 【Methods】A total of 160 cases after the abdomen womb excision surgery were divided into four groups, with 40 cases in each group. Group A, group B and group C were given dezocine and sufentanil combined with 0.5 μg/kg, 1.0 μg/kg and 1.5 μg/kg dexmedetomidine ,respectively,and group D was only given dezocine and sufentanil. Degree of pain (VAS), degree of comfort (BCS), Ramsay sedation score and incidence of adverse reactions were compared postoperative 1h (T1), 6h (T2), 12h (T3), 24h (T4), 48h (T5) amongst the four groups of patient-controlled intravenous analgesia (PCIA). 【Results】Compared with group A and D, the VAS scores at T2, T3 of group B and C were significantly decreased (P<0.05) and the BCS score at T3, T4, T5 were dramatically increased (P<0.05). Compared to g T3, T4, T5 moment BCS scores were significantly increased (P<0.05). Compared to group C, the Ramsay scores of group B at T3 and T4 were significantly decreased (P<0.05). The incidence of adverse reactions in group A and group B were lower than those of group C and D (P<0.05). 【Conclusion】 In abdominal hysterectomy, dezocine and sufentanil combined with 1.0 μg/kg dexmedetomidine postoperative analgesia has better effect, fewer adverse reactions, and more comfort; it is worth clinical attention.
王丹. 地佐辛+舒芬太尼复合不同剂量右美托咪定在经腹子宫切除术中的应用效果[J]. 医学临床研究, 2017, 34(3): 465-467.
WANG Dan. Application of Dezocine and Sufentanil Combined with Different Doses of Dexmedetomidine during Surgery in Abdominal Hysterectomy. JOURNAL OF CLINICAL RESEARCH, 2017, 34(3): 465-467.
[1] 田旻,李宇,张勤功.不同剂量右美托咪定复合舒芬太尼在宫颈癌根治术后镇痛效果的比较[J].山西医科大学学报,2013,44(12):997-999. [2] Han C,Ding W,Jiang W,et al.A comparison of the effects of midazolam, propofol and dexmedetomidine on the antioxidant system: A randomized trial[J].Exp Ther Med,2015,9(6):2293-2298. [3] 林莹,陈彦青,戴双波.舒芬太尼复合右美托咪定妇科腔镜手术术后镇痛效果观察[J].临床麻醉学杂志,2011,27(7):690-692. [4] 甘国胜,于红燕,吴树辉,等.右美托咪定超前镇静对腹腔镜胆囊切除术老年患者应激反应的影响[J].中国医药导刊,2014,16(5):834-835. [5] 龚继平,孟瑞霞.右美托咪定和地佐辛联合术后自控静脉镇痛研究[J].中国实用医药,2013,8(17):5-8. [6] 王贤东,丁韶丽,黄锦文.地佐辛、右美托咪定复合舒芬太尼在妇科腹式手术术后镇痛效果观察[J].甘肃医药,2014,33(10):750-753. [7] 李英娜,刘志建,侴伟平,等.盐酸右美托咪啶预防食管癌患者麻醉苏醒期心血管反应的观察[J].中华全科医学,2013,11(6):848-850. [8] 徐海军.地佐辛混合不同剂量右美托咪定用于术后镇痛对照研究[J].中国药业,2014,23(21):29-31. [9] 莫力,曾凯辉,张绍杰.不同剂量右美托咪定对腹腔镜下子宫全切患者术后地佐辛自控静脉镇痛效应的影响[J].广东医学,2015,36(4):608-610.
2017, Vol. 34 
