Abstract：【Objective】To investigate the clinical efficacy of docetaxel combined with oxaliplatin chemotherapy concurrent with radiotherapy for advanced cervical squamous-cell carcinoma. 【Methods】One hundred and twenty-five patients with locally advanced cervical squamous carcinoma in our hospital between July 2013-January 2015 were selected as the research subject. According to different therapeutic methods, patients were divided into the cisplatin group (59 cases) and Docetaxel＆Oxaliplatin group (TP group, 66 cases). The cisplatin group was given cisplatin chemotherapy concurrent with radiation therapy, while TP group was given docetaxel combined with oxaliplatin chemotherapy concurrent with radiotherapy. The curative effect and adverse reactions between the two groups were observed. 【Results】The total effective rate of TP group was 93.9% (62/66), which was significantly higher than that of the cisplatin group (81.3%, 48/59); the difference was statistically significant (P<0.05). The occurrence of gastrointestinal reaction, myelosuppression, radiation proctitis, and radiocystitis of TP group were 83.3%, 98.5%, 95.5% and 66.7%, respectively, while those in the cisplatin group were 91.5%, 96.6%, 91.5%, and 54.2%, respectively. There were no significantly statistical differences between the two groups (P>0.05). 【Conclusion】Docetaxel combined with oxaliplatin chemotherapy concurrent with radiotherapy for locally advanced cervical squamous cell carcinoma is both safe and effective.
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2017, Vol. 34 
