Abstract：【Objective】To analysis of radiofrequency ablation in the treatment of locally-advanced pancreatic carcinoma. 【Methods】We retrospectively analyzed the clinical data of 123 patients with locally-advanced pancreatic carcinoma. All the patients were divided into a radiofrequency group and a control group according to the radiofrequency ablation surgery. And then the perioperative and prognosis data of the two groups were analyzed and compared. 【Results】In our research, all patients were successfully completed surgery and there were no cases of perioperative death. The incidence of postoperative complications of radiofrequency group was 21.7% (control group rate 10.38%) and the incidence of pancreatic fistula was 6.5% (control group rate 1.3%). There were no statistical differences between the two groups. The 6 months, 1 year and 2 years survival rates of radiofrequency group and control group were 82.4%, 43.5%, 7.6% and 55.8%, 28%, 0%, the average survival time were 13.5±0.8 months and 9.1±0.3 months. The prognosis of radiofrequency group was significantly better than that of the control group (P<0.05). 【Conclusion】Radiofrequency ablation surgery is safe and effective in the treatment of locally-advanced pancreatic carcinoma.
李鹏;李澜滨;郭昊;刘彦. 射频消融术在局部进展期胰腺癌中的临床应用[J]. 医学临床研究, 2017, 34(3): 438-440.
LI Peng, LI-Lan-bin, GUO-Hao,et al. Analysis of Radiofrequency Ablation in the Treatment of Locally-Advanced Pancreatic Carcinoma. JOURNAL OF CLINICAL RESEARCH, 2017, 34(3): 438-440.
[1] Ng J, Zhang C, Gidea-Addeo D,et al. Locally advanced pancreatic adenocarcinoma: update and progress[J].J Pancreas,2012,13(2):155-158. [2] Jin ZD, Wang L, Li Z. Endoscopic ultrasound-guided celiac ganglion radiofrequency ablation for pain control in pancreatic carcinoma[J].Dig Endosc,2015,27(1):163-164. [3] Clavicn PA, Lesurtel M, Bossuyt PM, et al. Recommendations for liver transplantation for hepatocellular carcinoma: an international consensus conference report[J].Lancet Oncol,2012,13(1):11-22. [4] Cunningham D, Chau I, Stocken DD, et al. Phase Ⅲ randomized comparison of gemcitabine versus gemcitabine plus capecitabine in patients with advanced pancreatic cancer[J].Clin Oncol,2009,27(33):5513-5518. [5] Samka F, Quintus M, John HK. Radiofrequency ablation of the pancreas with and without intraluminal duodenal cooling in a porcine model[J].J Sur Research,2013,184(2):867-872. [6] 金震东, 王东, 王雷, 等. 内镜超声引导下射频消融治疗三例晚期胰腺癌的临床分析[J].中华胰腺病杂志, 2012,12(6):381-383. [7] Tombesi P, Di VF, Sartori S. Resection VS thermal ablation of small hepatocellular carcinoma:What's the first choice [J].World J Radiol,2013,5(1):1-4. [8] Girelli R, Frigerio I, Giardino A, et al. Results of 100 pancreatic radiofrequency ablations in the context of a multimodal strategy for stage Ⅲ ductal adenocarcinoma[J].Langenbecks Arch Surg,2013,398(1):63-69. [9] 金鑫, 吕少诚, 刘飞德, 等. 射频消融术治疗晚期胰腺癌的中远期疗效分析[J].国际外科学杂志, 2014,41(10):677-679. [10] 崔忠, 杜冬, 王振全, 等. 多极射频消融治疗不能切除胰腺癌的临床应用研究[J].华北国防医药, 2008,20(5):7-9.
2017, Vol. 34 
