Abstract：【Objective】To investigate the serum 25-hydroxy vitamin D [25 (OH) D] levels in children with Autism Spectrum Disorders (ASDs) and the relationship with clinical symptoms so as to provide clues and basis for the etiology and treatment of autism. 【Methods】Sixty cases of children with autism diagnosed in Hunan Children's Hospital from June 2014 to June 2016 were selected as the observation group , and other sixty healthy children for normal physical examination were selected as control group in the same period of time . Serum levels of 25 (OH) D of the two groups were determined by enzyme-linked immunosorbent assay (ELISA). Childhood autism Rating Scale (CARS) was used to assess the severity of autism. The levels of 25 (OH) D and CARS score were compared between the two groups. The incidence of sleep disorders and gastrointestinal disorders and their relationship with the level of 25 (OH) D between the two groups were also compared. 【Results】The 25 (OH) D level in the observation group was significantly lower than that in the control group, but it was not significantly associated with the CARS score. The incidence of sleep disorders and gastrointestinal dysfunction in the observation group was significantly higher than those in the control group (P<0.001), but the incidence of two of them was not significantly associated with levels of 25 (OH) D. 【Conclusion】The 25 (OH) D level of the observation group is significantly lower than that of the control, but there is no significant correlation with the severity of ASD, sleep disturbance and gastrointestinal dysfunction.
徐宁安;钟燕;赵莎;成新宁;邓美. 孤独症谱系障碍患儿维生素D水平及其与临床症状关系的研究[J]. 医学临床研究, 2017, 34(3): 421-423.
XU Ning-an, ZHONG Yan, ZHAO Sha,et al. Study on the Relationship between Vitamin D and Clinical Symptoms in Children with Autism Spectrum Disorders. JOURNAL OF CLINICAL RESEARCH, 2017, 34(3): 421-423.
[1] McGrath JJ, Burne TH, Féron F,et al. Developmental vitamin D deficiency and risk of schizophrenia: a 10-year update[J].Schizophr Bull,2010,36(6):1073-1078. [2] Deluca GC, Kimball SM, Kolasinski J,et al. The role of vitamin D in nervous system health and disease[J].Neuropathol Appl Neurobiol,2013,39(5): 458-484. [3] Vinkhuyzen AA, Eyles DW, Burne TH,et al. Gestational vitamin D deficiency and autism-related traits: the Generation R Study[J].Mol Psychiatry,2016,doi: 10.[epub ahead of print] [4] 陈正莉,莫巧字. 营养相关因素与儿童孤独症关系的研究进展[J].中国儿童保健杂志,2008,16(5)557-559. [5] 李素水,王霞,范彦蓉,等.孤独症患者胃肠失功能的临床研究[J].中国健康心理学杂志,2013,22(2):191-193. [6] 张霞娟,鲍莉芳,鲍舟君,等.儿童血清25-羟维生素D及钙磷水平调查[J].浙江预防医学,2012,24(6):5-7. [7] Yin K,Agrawal DK.Vitamin D and inflammatory diseases[J].J Inflanlm Res,2014,7:69-87. [8] 李诗韵,金宇,静进,等.孤独症谱系障碍儿童的睡眠行为[J].中国心理卫生杂志,2012,26(6):471-475. [9] 李娈娈,余晓丹.维生素D与睡眠关系的研究进展[J].中华儿科杂志,2014,52(4):263-266. [10] Brown A,Chow D,Murakami S,et al.Possible gastrointestinal symptoms in a subset of children with autism[J].Expert Rev GastroenteroI Hepatol,2010,4(2):125-127. [11] Brown AC. Autoimmune and gastrointestinal dysfunctions:does a subset of children with autism reveal abroader connection[J].Expert Rev Gastroenterol Hepatol,2011,5(4):465-477.
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