Effects of Total Glucosides of Paeony and Tripterygium Glycosides on Serum IL-12, TGF-β and IFN-γ Expression Levels and Immunologic Function in Patients with Oral Lichen Planus
XU Bi-kuan
Department of Stomatology, People's Hospital of Guanghan City, Guanghan, Sichuan, 618300, China
Abstract：【Objective】 To observe effects of total glucosides of paeony and tripterygium glycosides on serum IL-12, TGF-β and IFN-γ expression levels and immunologic function in patients with oral lichen planus (OLP). 【Methods】The clinical data of 64 patients with OLP treated in our stomatology and dermatology divisions from March 2010 to March 2012 were retrospectively analyzed and divided into the control group and the treatment group according to the treatment method. Patients in the control group were given oral total glucosides of paeony capsules while those in the observation group were given oral tripterygium glycosides tablets. The clinical effect in the two groups after the treatment were compared. Enzyme linked immunosorbent assay was applied to detect IL-12, TGF-β and IFN-γ expressions in serum of two groups before and after the treatment, while flow cytometry was used to detect cellular immunity markers CD4+, CD8+, CD4+/CD8+ and other T lymphocyte subsets changes.【Results】The total effective rate was 84.37% (27/32) in the observation group, which was significantly higher than that in the control group (65.63%, 21/32); the difference was statistically significant (χ2=7.682,P<0.05). After treatment, the expressions of IL-12 and IFN-γ in the serum of the observation group were significantly lower than those of the control group, while the expression of TGF-β was significantly higher than that of the control group (P<0.05). The immunity markers CD4+ and CD8+ in the observation group after the treatment were significantly lower than those in the control group, while CD4+/CD8+ was significantly higher than the control group (P<0.05). During the half-year follow-up, the recurrence rate was 9.38% (3/32) in the observation group, which was significantly lower than that in the control group (21.88%, 7/32); the difference was statistically significant (χ2=6.552,P<0.05). The incidence of adverse reactions in the observation group was 25.00% (8/32), which was significantly higher than that in the control group (9.38%, 3/32) (χ2=7.421,P<0.05).【Conclusion】The effect of total glucosides of paeony and tripterygium glycosides is significant in the treatment of oral lichen planus. They play a role by regulating cellular immunity, influencing expression and secretion of related cytokines. The efficacy of tripterygium glycosides is better than total glucosides of paeony.
徐必宽. 白芍总苷与雷公藤多苷对口腔扁平苔藓患者血清IL-12、TGF-β、IFN-γ表达水平及免疫功能的影响[J]. 医学临床研究, 2017, 34(2): 330-333.
XU Bi-kuan. Effects of Total Glucosides of Paeony and Tripterygium Glycosides on Serum IL-12, TGF-β and IFN-γ Expression Levels and Immunologic Function in Patients with Oral Lichen Planus. JOURNAL OF CLINICAL RESEARCH, 2017, 34(2): 330-333.
2017, Vol. 34 
