Abstract：【Objective】To explore the influencing factors of early neurological deterioration in patients with cerebral infarction.【Methods】A total of 108 patients with cerebral infarction treated in our hospital were selected from January 2013 to January 2016. According to whether or not the patient was suffering from early neurological deterioration, patients were divided into the deterioration group (n=38) and the non-deterioration group (n=70). The differences of baseline data, past history, clinical signs and laboratory results were observed and compared between the two groups, and by multiple factor analysis, the significant factors that affected the early neurological deterioration were observed.【Results】The proportion of hypertension, diabetes, TIA or stroke, hyperlipidemia, and atrial fibrillation history in the deterioration group was higher than that in the non-deterioration group(P＜0.05). Compared to the non-deterioration group, patients in the deterioration group had higher body temperature, higher scores of nerve function defect, lower systolic and diastolic blood pressure(P＜0.05), higher level of D-dimer and leukocyte, longer prothrombin time and lower level of C reactive protein(P＜0.05). Multivariate logistic regression analysis showed that parameters high score of nerve function defect (OR=1.993), high body temperature (OR=3.012), lower systolic blood pressure (OR=2.942), low diastolic blood pressure (OR=1.838), hypertension (OR=3.522), diabetes mellitus (OR=1.050), transient ischemic attack (TIA) or stroke (OR=1.442), and atrial fibrillation (OR=3.522)] were significant independent risk factors that occurred in the early neurological deterioration(P＜0.05).【Conclusion】High score of neural function defect, fever, lower systolic and diastolic pressure, hypertension, diabetes, stroke, TIA and atrial fibrillation history are high-risk factors for early neurological deterioration occurred in patients with cerebral infarction. Therefore, clinical attention should be paid to those influencing factors for prevention.
邓榕;马丽华;郭靖;陈永平;周杰;陈胜利;刘勇. 脑梗死患者早期神经功能恶化的影响因素分析[J]. 医学临床研究, 2017, 34(2): 318-321.
DENG Rong; MA LI-hua; GUO Jing,et al. Influencing Factors of Early Neurological Deterioration in Patients with Cerebral Infarction. JOURNAL OF CLINICAL RESEARCH, 2017, 34(2): 318-321.
2017, Vol. 34 
