Abstract：【Objective】To study the effect of dexmedetomidine on post-anesthesia delirium in children undergoing tonsillectomy with sevoflurane anesthesia. 【Methods】A total of 80 cases of tonsillectomy in children under general anesthesia were randomly divided into an observation group and a control group, with 40 cases in each group. All patients received intravenous injections of fentanyl 0.2 g/kg, propofol 3mg / kg, and cis atracurium 0.2mg/kg for the intubation of the endotracheal tube. Then, all patients inhaled 2%~3.5% sevoflurane to maintain anesthesia during operation. After inserting endotracheal tube, patients in the observation group received dexmedetomidine injection 0.5μg/kg while patients in the control group received the same dosage of saline injections. Post-anesthesia agitation in the two groups during the anesthesia recovery period was compared. 【Results】PAED (Pediatric Anesthesia Emergence Delirium Scale) score of the observation group (8.0±1.5) was significantly lower than that of the control group (11.9±1.7), and the difference was statistically significant (P<0.05). The incidence of agitation and adverse reactions in the observation group was significantly lower than that in the control group (P<0.05). The PACU (Post-Anesthesia Care Unit) retention time of the observation group was significantly lower than that of the control group (P<0.05). The operation time and extubation time of the control group and observation group was not statistically significant (P>0.05). 【Conclusion】Dexmedetomidine can reduce infant restlessness and help children smoothly wake up during the anesthesia recovery period. It also reduces postoperative adverse reactions. So, it is worth being popularized in clinical application.
宋宇龙. 右美托咪定对扁桃腺切除术患儿七氟醚复合麻醉苏醒期躁动的影响[J]. 医学临床研究, 2017, 34(2): 282-284.
SONG Yu-long. Effect of Dexmedetomidine on Post-Anesthesia Delirium in Children Undergoing Tonsillectomy with Sevoflurane Combined Anesthesia. JOURNAL OF CLINICAL RESEARCH, 2017, 34(2): 282-284.
[1] 肖凌燕.右美托咪定对七氟醚复合麻醉斜视矫正术患儿苏醒期躁动的影响[J].中国现代药物应用,2015,02(1):14-15. [2] 徐斌,艾麟,梁是,等.咪达唑仑和右美托咪定对七氟醚麻醉苏醒期躁动影响的对比[J].湖南师范大学学报(医学版),2015,01(2):110-112. [3] 周海东.瑞芬太尼联合七氟烷对小儿麻醉苏醒期躁动的效果[J].贵阳医学院学报,2015,03(3):313-315. [4] 陈景艳.右美托咪定对小儿七氟醚麻醉苏醒期躁动的影响[J].医药论坛杂志,2015,03(1):140-141. [5] 贾英萍,李郑琛,邱永升.右美托咪定滴鼻复合七氟醚吸入麻醉在小儿舌系带成形术中的应用[J].新乡医学院学报,2015,08(5):732-734. [6] Nicolls MR,Haskins K,Flores SC.Oxidant stress,immune dysregulation,and vascular function in type 1 diabetes[J].Antio Xid Redox Signal,2012,9(7):879-889. [7] Gokce N,VitaJA,Mc Donnell M,et al.Effect of medical and surgical weightloss on endothelial vasomotor function in obese patients[J].Am J Cardiol,2011,95(2):266-268. [8] Lteif AA,Han K,Mather KJ.Obesity,insulin resistance,and the metabolic syndrome:determinants of endothelial dysfunction in whites and blacks[J].Circulation,2013,112(1):32-38. [9] Zhang Y,Li W,Yan T,et al.Early detection of lesions of dorsal artery of foot in patients with type 2 diabetes mellitus by high-frequency ultrasonography[J].J Huazhong Univ Sci Technol(Med Sci),2011,29(3):387-390. [10] Foley RN,Parfrey PS,Sarnak MJ.Epidemiology of cardiovasc-ular disease in chronic renal disease[J].J Am Soc Nephrol,2013,9(12Suppl):S16-23.
2017, Vol. 34 
