血清C反应蛋白、胰蛋白酶原-2、血小板活化因子在ERCP术后急性胰腺炎早期诊断中的临床意义

doi:10.3969/j.issn.1671-7171.2017.02.022

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摘要【目的】探讨血清C反应蛋白(CRP)、胰蛋白酶原-2、血小板活化因子(PAF)在ERCP术后急性胰腺炎早期诊断中临床意义。【方法】选择本院消化内科2014年1月至2016年10月收治的行经内镜逆行胰胆管造影术(ERCP)患者108例为研究对象,术后根据患者是否发生急性胰腺炎分为胰腺炎组,高淀粉酶血症组以及对照组。分别在行ERCP前、术后6 h以及24 h检测患者淀粉酶、CRP、胰蛋白酶原-2以及PAF。【结果】术后6 h,胰腺炎组及高淀粉酶组血清淀粉酶、CRP水平显著升高;胰腺炎组术后24 h淀粉酶、CRP水平持续升高,而高淀粉酶组有所下降,与术前比较差异均有统计学意义(P＜0.05);术后6 h及24 h,胰腺炎组血清淀粉酶、CRP水平最高,其次为高淀粉酶组,对照组最低,三组间比较差异均有统计学意义(P＜0.05)。术后6 h,胰腺炎组及高淀粉酶组血清胰蛋白酶原-2、PAF显著升高,术后24 h两组血清胰蛋白酶原-2、PAF有所下降,但与术前比较差异均有统计学意义(P＜0.05);术后6 h及24 h,胰腺炎组血清胰蛋白酶原-2、PAF最高,其次为高淀粉酶组,对照组最低,三组间比较差异均有统计学意义(P＜0.05)。【结论】ERCP术后急性胰腺炎患者在早期就出现CRP、胰蛋白酶原-2、PAF水平升高,临床上可通多检测CRP、胰蛋白酶原-2、PAF,及时判断患者是否出现急性胰腺炎情况,及时给予预防和处理。

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	刘雨晴
	卢启明

关键词 ： C反应蛋白质, 胰蛋白酶原, 血小板活化因子, 胰胆管造影术, 内窥镜逆行/副作用, 胰腺炎/病因学, 急性病, 早期诊断

Abstract：【Objective】To discuss clinical significance of serum CRP, trypsin -2 and PAF in early diagnosis of acute pancreatitis after ERCP. 【Methods】 A total of 108 cases underwent ERCP in the department of digestive medicine from Jan 2014 to Dec 2016 was selected as subjects. After ERCP, the patients were divided into pancreatitis group, high amylase group and control group according to the occurrence of acute pancreatitis. Amylase, CRP, trypsin -2 and PAF were detected before ERCP , 6h and 24h after ERCP . 【Results】 At 6h after ERCP, serum amylase and CRP levels of the pancreatitis group and the high amylase group increased significantly; at 24h after ERCP, serum amylase and CRP levels of the pancreatitis group continued to rise, and the high amylase group decreased, which were higher than those before ERCP,the differences were statistically significant(P＜0.05). At 6h and 24h after ERCP, serum amylase and CRP levels of the pancreatitis group were the highest, the next was the high amylase group, and the control group was the lowest, which showed significant difference in the three groups(P＜0.05). At 6h after ERCP, trypsin -2 and PAF levels of the pancreatitis group and the high amylase group increased, but decreased 24h after ERCP, which were higher than those before ERCP(P＜0.05). At 6h and 24h after ERCP, serum trypsin-2 and PAF levels of the pancreatitis group were the highest, the next was the high amylase group, and the control group was the lowest, which showed significant difference statistically(P＜0.01). 【Conclusion】 CRP, trypsin-2 and PAF levels increased in early stage after ERCP in patients with acute pancreatitis.CRP,trypsin-2 and PAF can be detected through clinical examination to determine whether patients are with acute pancreatitis,so as to prevent and deal with it in time.

Key words： C-Reactive Protein Trypsinogen Platelet Activating Factor Cholangiopancreatography, Endoscopic Retrograde/AE Pancreatitis/ET Acute Disease Early Diagnosis

收稿日期: 2016-12-05

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引用本文:

刘雨晴;卢启明. 血清C反应蛋白、胰蛋白酶原-2、血小板活化因子在ERCP术后急性胰腺炎早期诊断中的临床意义[J]. 医学临床研究, 2017, 34(2): 276-278.
LIU Yu-qing; LU Qi-ming. Clinical Significance of Serum CRP, Trypsin -2 and PAF in Early Diagnosis of Acute Pancreatitis after ERCP. JOURNAL OF CLINICAL RESEARCH, 2017, 34(2): 276-278.

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http://www.jcr.net.cn/CN/10.3969/j.issn.1671-7171.2017.02.022 或 http://www.jcr.net.cn/CN/Y2017/V34/I2/276

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