Abstract：【Objective】To study the influence of calcitriol soft capsules on urine protein of patients with diabetic nephropathy (DN). 【Methods】From January 2014 to April 2016, 86 patients with DN were chosen as study objects. All patients were divided into 2 groups: the control group and the study group. The 43 patients in the control group were treated with anti-hypertension/ hyperglycemia/ hyperlipidemia, while the 43 patients in the study group were treated with calcitriol soft capsules for 3 months in addition to anti-hypertension/ hyperglycemia/ hyperlipidemia. The effect rate, SCr, uAER, eGFR and UAlb/Cr were compared between two groups. 【Results】After treatment, the uAER, SCr and UAlb/Cr of patients in the two groups decreased significantly (P＜0.05), but the levels in the study group showed more dramatic decrease (P＜0.05). There was no significant change in eGFR before and after treatment in the two groups (P>0.05). Compared to before treatment, the systolic blood pressure (SBP), fasting blood glucose (FPG), glycosylated hemoglobin (HbA1c) and low density lipoprotein cholesterol (LDL-C) in two groups were significantly decreased (P<0.05), while 1,25(OH)2D3 and high density lipoprotein cholesterol (HDL-C) were significantly higher than those before treatment (P<0.05). After treatment, the levels of FPG and HbA1c were significantly lower in the study group than those in the control group (P<0.05), but the level of 1,25(OH)2D3 was significantly increased (P<0.05). The level of 1,25 (OH)2D3 after treatment was significantly correlated with clinical efficacy, uAER, UAlb / Cr and blood pressure (P<0.05). The effect rate of study group was 83.72%(36/43) compared to that of the control group, which was 62.79%(27/43); the difference had statistical significance (χ2=4.807,P＜0.05). 【Conclusion】Calcitriol soft capsules can help increase the kidney function of patients with DN, as well decrease the urine protein.
郭丽萍;胡春;卞志翔;顾慧益;张玉梅;陈佩华;朱士建. 骨化三醇胶丸对糖尿病肾病患者尿蛋白水平的影响[J]. 医学临床研究, 2017, 34(2): 268-271.
GUO Li-ping; HU Chun; BIAN Zhi-xiang,et al. Influence of Calcitriol Soft Capsules on Urine Protein of Patients with Diabetic Nephropathy. JOURNAL OF CLINICAL RESEARCH, 2017, 34(2): 268-271.
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2017, Vol. 34 
