Effects of Astragalus Polysaccharide Injection on Liver Function, Lipid and Glucose Metabolism, and Immune System in Patients Undergoing Radiotherapy and Chemotherapy after Lung Cancer Surgery
YAO Yan-chun; ZHANG Zhen
The Central Hospital of Anshan ,Anshan City, LiaoLin Province, 114001
Abstract：【Objective】To explore the effects of Astragalus polysaccharides injection on liver function, lipid and glucose metabolism, and immune function in patients undergoing radiotherapy and chemotherapy after lung cancer surgery. 【Methods】Eighty-seven patients with NSCLC were divided into the observation group (A group,n=45) and the control group (B group,n=42). Patients in the two groups were treated with the same radiotherapy and chemotherapy plan after surgery. In addition, patients in the A group were treated with Astragalus polysaccharides injection. Liver function indexes [alanine transaminase (ALT), aspartate aminotransferase (AST)], glucose and lipid metabolism indexes [fasting plasma glucose (FPG), postprandial 2h plasma glucose (2hPG), high density lipoprotein (HDL-C)] and immune indexes(CD4+,CD8+)] were compared between the two groups before and after treatment. 【Results】Before treatment, there were no significant differences in all indexes between the two groups(P>0.05). After treatment, ALT and AST in the two groups were increased (P<0.05). However, those changes in the A group were lower than those in the B group (P<0.05). In the comparison of before and after treatment, there were no significant changes in levels of FPG, 2hPG and HDL-C in the A group (P>0.05). On the other hand, levels of FPG, 2hPG, and HDL-C in B group after treatment were higher than before treatment and the levels in the A group after treatment (all P<0.05). After treatment, there were no significant changes of CD8+ between the two groups (P>0.05). However, the CD4+ rate in the A group after treatment was higher than that before treatment and post-treatment in B group (all P<0.05). 【Conclusion】Astragalus polysaccharides injection can effectively reduce liver function damage, enhance immune function, relieve the elevation of blood glucose and blood lipids induced by chemotherapy and improve the tolerance of patients undergoing radiotherapy and chemotherapy after lung cancer surgery.
姚艳春;张琛. 黄芪多糖注射液对肺癌术后放化疗患者肝功能、脂糖代谢及免疫功能的影响[J]. 医学临床研究, 2017, 34(2): 258-260.
YAO Yan-chun; ZHANG Zhen. Effects of Astragalus Polysaccharide Injection on Liver Function, Lipid and Glucose Metabolism, and Immune System in Patients Undergoing Radiotherapy and Chemotherapy after Lung Cancer Surgery. JOURNAL OF CLINICAL RESEARCH, 2017, 34(2): 258-260.
2017, Vol. 34 
