Abstract：【Objective】To explore the postoperative analgesia effect of oxycodone injection as preemptive analgesia in patients who underwent patient-controlled intravenous analgesia (PCIA) after modified radical mastectomy.【Methods】Ninety patients with breast cancer (ASA Ⅰ~Ⅱ) who were scheduled for modified radical mastectomy and required PCIA were randomly divided into 3 groups, A、B and C, with 30 cases in each group. Patients in A group received the preemptive analgesia with oxycodone (0.1mg/kg) 10 minutes before anesthesia induction, while patients in B and C groups received intravenous injection of saline (10mL) . After surgery, all patient received PCIA with different concentrations of sufentanil,[A and B group received sufentanil 1.0 μg/(kg·100 mL) while C group received sufentanil 2.0 μg/(kg·100 mL)]. PCIA settings were: background infusion dose at 2 mL/h, patient-controlled dose of 3mL, and lockout interval for 15 minutes. Other drugs were the same in each group. Each patient's awakening and extubation time, the VAS at 2h, 12h, 24h, and 48h postoperation and adverse events (nausea, vomiting and dizziness) were observed and recorded. 【Results】There were no statistical significance in awakening and extubation times among the three groups(P>0.05).Compared with the patients in B group, the patients' VAS in A and C groups were significantly lower(P<0.05). However, there was no statistically significant difference between the A and C groups(P>0.05).Compared with the patients in the C group, the numbers of adverse events in A and B groups were significantly lower(P<0.05), but there was no statistically significant difference between A and B groups(P>0.05).【Conclusion】Preemptive analgesia with oxycodone injection can be effectively and safely used in patients undergoing modified radical mastectomy. It has no effect on patient's awakening and extubation time and can lower the total dosage of sufentanil given, which reduces the incidence of adverse reactions.
何双亮;甘建辉;蔡海峰;于虹;王承志;吴雨思. 盐酸羟考酮注射液超前镇痛对乳腺癌改良根治术术后镇痛的影响[J]. 医学临床研究, 2017, 34(2): 256-256.
HE Shuang-liang; GAN Jian-hui; CHAI Hai-feng,et al. Effects of Oxycodone Injection as Preemptive Analgesia on Postoperative Analgesia in Breast Cancer Patients after Modified Radical Mastectomy. JOURNAL OF CLINICAL RESEARCH, 2017, 34(2): 256-256.
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2017, Vol. 34 
