Abstract:【Objective】To investigate the influencing factors of poor effect of calcium supplementary treatment in patients with maintenance hemodialysis (MHD)-induced osteoporosis. 【Methods】A total of 136 patients with MHD-induced osteoporosis were analyzed retrospectively. According to the effect of calcium supplementary treatment, they were divided into the excellent group (n=84) and the poor group (n=52). General information was compared between the two groups. Analysis was performed to analyze the related factors influencing poor effect of calcium supplementary treatment in patients with MHD-induced osteoporosis. 【Results】 There were no significant differences in BMI levels, hyperlipidemia and hypertension status, and bone mineral density T value before calcium supplement between the two groups (P>0.05). The proportions of age, gender (female), diabetes rate, MHD time, and unhealthy living habits (smoking, drinking, staying up overnight) during the treatment in the excellent group were significantly lower than those in the poor group, while daily walking distance and time was significantly more than that of the poor group (P<0.05). The multivariate logistic regression analysis showed that age, gender, diabetes, MHD time, daily walking habits, smoking, drinking, and staying up late were the related factors influencing the effect of calcium supplementary treatment in patients with MHD-induced osteoporosis (P<0.05). 【Conclusion】Age, being female, diabetes, MHD time, smoking, drinking and staying up late during the treatment are the independent risk factors influencing the effect of calcium supplementary treatment in patients with MHD-induced osteoporosis, while daily exercise is the protective factor.