Abstract：【Objective】To investigate clinical effect of the injectable compound venom recipe on the immune function of gastric carcinoma patients underwent postoperative chemotherapy. 【Methods】The patients (84 cases) with gastric cancer were randomly divided into control group and observation group according to the age, gender, tumor location and pathological stage of patients. The control group were treated by 12 course of chemotherapy program FOLFOX4; the patients in observation group were additionally implemented the treatment with the injectable compound venom recipe during FOLFOX4 chemotherapy therapy. It's compared that the change of immune indicators before and after chemotherapy and the improvement of patients' life quality, the incidence of adverse reaction during the process of chemotherapy . 【Results】 In the immune indicator detection experiments before and after chemotherapy, we observed that the patients in observation group possessed significantly higher levels of peripheral blood immunoglobulin (IgG, IgA, IgM) and complement components (C3 and C4) than those of the control group (P<0.05), and the number and proportion of CD4+ T cells in peripheral blood of patients in the observation group were significantly higher than that of the control group (P<0.05). KPS score of quality of life after chemotherapy proved that the scores of observation group patients was significantly higher than that of the control patients, while the effectiveness of chemotherapy in observation group was also significantly higher than that in the control group (P<0.05). Comparing with control group, the incidence of adverse reaction as diarrhea, infection, thrombocytopenia, leukopenia, lower hemoglobin, the decrease of glutamic-oxalacetic transaminase and glutamic-pyruvic transaminase were significantly lower than those in the control group (P<0.05); Whereas, the incidence of adverse reaction as anorexia, hair loss, nausea, vomiting, arrhythmia, creatinine elevation, urea nitrogen increase, total bilirubin increase and pain, had no significant difference between the control and the observation group (P>0.05). 【Conclusion】The useage of injectable compound venom recipe can significantly improve immune function and life quality during postoperative chemotherapy for patients with gastric cancer, and reduce the side reaction of chemotherapy, which is worthy of clinical application.
鲁加煜;张勇. 复方蟾酥注射液用于胃癌患者术后化疗的临床研究[J]. 医学临床研究, 2017, 34(2): 243-282.
LU Jia-yu; ZHANG Yong. Clinical research on Injectable Compound Venom Recipe Using in Postoperative Chemotherapy of Gastric Carcinoma Patients. JOURNAL OF CLINICAL RESEARCH, 2017, 34(2): 243-282.
2017, Vol. 34 
