Abstract：【Objective】To investigate the prevalence of Tc17 cells in the peripheral blood of patients with osteosarcoma. 【Methods】Flow cytometry was used to evaluate the prevalence of Tc17 cells in the peripheral blood of 41 patients with osteosarcoma and 17 healthy people. In addition, the concentration of IL-17 was measured. The relationship between peripheral blood Tc17 cell level with the concentration of IL-17 and tumor stage was determined statistically.【Results】The prevalence of Tc17 cells in the peripheral blood of patients with osteosarcoma (3.18±1.99%) increased greatly with increased levels of IL-17, compared with the normal control subjects (0.72±0.46%). The differences were statistically significant (P<0.01). The percentage of Tc17 cells was not associated with the concentration of IL-17 or the stages of osteosarcoma. 【Conclusion】The prevalence of Tc17 cells is increased in the peripheral blood of patients with osteosarcoma.These cells may negatively regulate antitumor immune response of patients.
陆凌云;钟永;戴哲浩. 骨肉瘤患者外周血Tc17细胞的比例及其临床意义[J]. 医学临床研究, 2017, 34(2): 213-215,218.
LU Ling-yun; ZHONG Yong; DAI Zhe-hao. Prevalence of Tc17 Cells in the Peripheral Blood of Patients with Osteosarcoma and its Clinical Significance. JOURNAL OF CLINICAL RESEARCH, 2017, 34(2): 213-215,218.
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2017, Vol. 34 
