Abstract：【Objective】To investigate the changes of voltage-gated calcium channels (VGCCs) in the rostral ventromedial medulla of SD rats under morphine-induced hyperalgesia. 【Methods】The expression of a1C and a1H subunit proteins in the rostral ventromedial medulla (RVM) was detected by western blot. The VGCCs current of RVM neurons was recorded by the whole-cell patch-clamp technique. 【Results】Our results indicated that the expression of α1C subunit in the RVM significantly increased under morphine-induced hyperalgesia, which was followed by the significant increase in total VGCCs currents and L-type VGCCs currents. 【Conclusion】This data implicates that α1C-subunit-containing L-type VGCCs in RVM may play an essential role as a cellular mechanism leading to hyperalgesia.
王静;李敏;李自成. 吗啡处理对大鼠延髓头端腹内侧区的L-型电压门控钙通道蛋白与电流的影响[J]. 医学临床研究, 2017, 34(2): 209-212.
WANG Jing; LI Min; LI Zi-cheng. Effects of Morphine Treatment on the Protein Levels and Currents of L-type Voltage-gated Calcium Channels in the Rostral Ventromedial Medulla of Rats. JOURNAL OF CLINICAL RESEARCH, 2017, 34(2): 209-212.
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2017, Vol. 34 
