Abstract：【Objective】To explore the clinical efficacy of intensive plasma exchange and glucocorticoid therapy on rapidly progressive glomerulonephritis. 【Methods】 Fifty-nine patients with rapidly progressive glomerulonephritis (RPGN) were analyzed retrospectively. All patients were treated with combined with adrenocortical hormone therapy. The patient's outcomes were analyzed.【Results】Patients accepted intensive plasma exchange treatment with an average of 13.2±2.6 times, had an average hospital length of 72.8±11 days , average hematuria disappearance procedure of 27.4±11.6 days, mean edema subsided time of 15.8±5.1 days, and blood pressure recovery of 14.7±4.2 days. After 4 weeks and 8 weeks of treatment, there were evidence the showed improvement of ALB, eGFR, and 24h urine volume with statistical significances (P<0.05). On the other hand, urine protein, serum creatinine (SCR), anti GBM (anti-glomerular basement membrane) antibody value were reduced significantly after treatment, the difference were also statistically significant (P<0.05). Of those 59 patients, 15 (25.42%) were cured, 34 improved (57.63%), and 10 were invalidated (16.95%). The 10 invalid patients after discharge were treated with long-term hemodialysis in our outpatient hemodialysis center. 【Conclusion】Intensive plasma exchange combined with adrenal cortical hormone treatment is valuable for rapidly progressive glomerulonephritis.
2017, Vol. 34 
