Abstract：【Objective】To explore the effects of dexmedetomidine on oxidation resistance, nitric oxide (NO) level and cardiopulmonary function in patients undergoing lung surgery. 【Methods】A total of 76 patients who received pulmonary surgery under general anesthesia were divided into a control group (group C) and a dexmedetomidine group (group D), with 38 cases each. Tumor necrosis factor (TNF-α), interleukin-6 (IL-6), NO level, malonaldehyde (MAD), and superoxide dismutase (SOD) were detected before opening the chest (T0), 60min after OLV (T1) and at the end of operation (T2). Stroke index (SI), cardiac index (CI), airway plateau pressure, air way resistance and lung compliance at T0 to T2 were determined as well. Adverse drug reactions in two groups during the perioperative period were recorded. 【Results】Compared to those at T0, TNF-α, IL-10, TNF-α, IL-6, IL-10, NO, MDA in the two groups at T1 and T2 were significantly increased, while SOD level was significantly decreased (P<0.05). Compared to group C at T1 and T2, TNF-α, IL-10, NO, MDA in the group D were significantly lower; however, SOD was significantly higher (P<0.05). In group D, there were no significant changes in SI, CI, airway plateau pressure, air way resistance and lung compliance at T1 and T2 compared to T0 (P>0.05). The above indexes in group C at T1 were not changed (P>0.05), but SI, CI at T2 were significantly decreased. Airway plateau pressure, airway resistance and lung compliance were significantly increased (P<0.05). Compared to group C at T2, SI and CI in group D were significantly higher and airway plateau pressure, air way resistance and lung compliance were significantly lower (P<0.05). The adverse reaction rate during the perioperative period of group D was 7.89%, was significantly lower than that of group C, which was 26.32% (P<0.05). 【Conclusion】 The application of dexmedetomidine in lung surgery during the perioperative period can reduce inflammatory levels and alleviate oxidative stress injury. It is beneficial to the recovery of cardiopulmonary function.
黎秀萍. 右美托咪定对肺部手术患者抗氧化能力、NO水平及心肺功能的影响[J]. 医学临床研究, 2017, 34(1): 29-32,35.
LI Xiu-ping. Effects of Dexmedetomidine on Oxidation Resistance, NO Level and Cardiopulmonary Function in Patients Undergoing Lung Surgery. JOURNAL OF CLINICAL RESEARCH, 2017, 34(1): 29-32,35.
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2017, Vol. 34 
