Abstract：【Objective】To explore the clinical significance of detection of gastric juice α1-antitrypsin in diagnosis of gastric cancer.【Methods】114 patients with gastric cancer (gastric cancer group), 43 patients with benign gastric diseases (benign gastric diseases group) and 25 healthy people (control group) who underwent upper gastrointestinal endoscopic examination in our hospital from February 2011 to April 2013 were selected as research subjects. The levels of concentration of gastric juice α1-antitrypsin of these three groups were examined respectively by ELISA. The experimental and clinical data were analyzed statistically.【Results】The concentration of gastric juice α1-antitrypsin (1368.7 ± 498.4) μg/dL in gastric cancer group was significantly higher than that in the benign gastric disease group (345 ± 96.5) μg/dL and the healthy group (31.2±17.3) μg/dL, and the difference was statistically significant (P<0.05); Gastric cancer sensitivity, specificity, accuracy of gastric juice α1-antitrypsin exams were 90.4%, 89.7% and 90.1%; the α1 antitrypsin concentration of Ⅲ~Ⅳ gastric cancer patients was significantly higher than that of I ~ II patients, the difference was statistically significant (P<0.05).【Conclusion】The concentration detection of α1-antitrypsin in gastric juice can improve the accuracy in the diagnosis of gastric cancer and has great clinical value of further studying.
史向军;黄新余;汪昱;郑起;冯昌宁. 胃液α1-抗胰蛋白酶检测在胃癌诊断中的意义[J]. 医学临床研究, 2017, 34(1): 17-19.
SHI Xiang-jun, HUANG Xin-yu, WANG Yu,et al. Clinical Significance of Concentration Detection of Gastric Juice α1-antitrypsin in Diagnosis of Gastric Cancer. JOURNAL OF CLINICAL RESEARCH, 2017, 34(1): 17-19.
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