Abstract：【Objective】To observe the effects of a new antidiabetic drug Liraglutide on injury of neonatal rat cardiomyocytes induced by hypoxia / reoxygenation(H/R).【Method】 Wistar rat myocardial cells were cultured in vitro and were divided into three groups: simple H/R group(group A ), Liraglutide + H/R group(group B ), and normal control group (group C). In addition to the normal control group, the remaining two groups were injured by H/R. Dehydrogenase (LDH), malondialdehyde (MDA) levels, superoxide dismutase (SOD) activity, and apoptotic cardiomyocytes were detected in the three groups. 【Results】Compared with group C, MDA, LDH levels, and apoptosis rate in group A were significantly higher, and the activity of SOD was lower (P<0.01). Compared with group A, the LD H, MDA level, and cell apoptosis rate in group B was significantly lower (P<0.01), but was still higher than those in group C (P<0.01). Compared with groups B and C, the SOD activity was significantly higher in group A (P<0.01). 【Conclusion】H/R can damage of myocardial cells and increase cell apoptosis. As glucagon like peptide-1 analogue, Liraglutide shows potential cardioprotective effects by directly acting on myocardial cells, which includes reducing myocardial cell injury and inhibiting the apoptosis caused by H/R.
周雪;李贲;张文娟;贾宁;李志红;李宝新;郭淑芹. 利拉鲁肽对缺氧/复氧诱导的乳鼠心肌细胞损伤的影响[J]. 医学临床研究, 2016, 33(12): 2346-2349.
ZHOU Xue, LI Ben, ZHANG Wen-juan,et al. Effects of Liraglutide on the Injury of Neonatal Rat Cardiomyocytes Induced by Hypoxia / Reoxygenation. JOURNAL OF CLINICAL RESEARCH, 2016, 33(12): 2346-2349.
2016, Vol. 33 
