Abstract：【Objective】To evaluate the effect of moxifloxacin intervention therapy on serum PCT and sTREM-1 in patients with multiple drug resistance tuberculosis(MDR-TB).【Methods】One hundred and forty patients with MDR-TB were enrolled in this study and randomly divided into two groups: the moxifloxacin group(n=70)and the control group. Dynamic changes of serum PCT and sTREM-1 levels and the clinical efficacy were observed in 2 and 6 months after treatment.【Results】After 6 months of treatment, the effective rate of the observation group was 85.7% (60/70), which was significantly higher than that of the control group 65.7% (46/70), and the difference was statistically significant (χ2=5.962,P=0.015<0.05). The levels of serum sTREM-1 and PCT were significantly decreased in the observation group after treatment, the serum sTREM-1 level was significantly lower than that of the control group at 2 and 6 months, and the difference was statistically significant (mean P<0.05 ); the serum PCT level was significantly lower than that the control group after 6 months of treatment, the difference was statistically significant (P<0.05). The differences of the serum PCT and sTREM-1 levels of Moxifloxacin group(both in the effective subgroup or ineffective subgroup ) were statistically significant 6 months before or after treatment (P<0.05); In the control group, PCT did not show a clear downward trend after treatment, while the level of sTREM-1 was decreased, but there was no significant difference(P>0.05).【Conclusion】Moxifloxacin can effectively reduce serum PCT and sTREM-1 levels in patients with MRD-TB and can improve the treatment efficiency.
张启龙;高隆;杨俊. 莫西沙星对多重耐药肺结核患者血清PCT和sTREM-1水平的影响[J]. 医学临床研究, 2016, 33(12): 2295-2299.
ZHANG Qi-long GAO Long YANG Jun. Influence of Moxifloxacin on Serum Levels of PCT and sTREM-1 in Patients with Multiple Drug Resistance Tuberculosis. JOURNAL OF CLINICAL RESEARCH, 2016, 33(12): 2295-2299.
[1] 王成勇,吴河,王伟,等.PCT、HS-CRP 和 FIB 检测在肺结核治疗中的意义[J].临床肺科杂志,2015,20(9):1608-1610. [2] 陈妍.莫西沙星联合抗结核药治疗耐药性结核临床疗效观察[J].临床肺科杂志,2013,18(2):309-311. [3] 尹凤鸣,周友乾,任彬,等.血清降钙素原与sTREM-1水平对多重耐药肺结核患者临床预后的相关性研究[J].临床肺科杂志,2015,20(10):1770-1773. [4] 中华医学会结核病学分会.肺结核诊断和治疗指南[J]. 中华结核和呼吸杂志,2001,24( 2) : 70-74 [5] Markova M. Brodska H. Malickova K. et al. Substantially elevated C-reactive protein (CRP), together with low levels of procalcitonin (PCT), contributes to diagnosis of fungal infection in immunocompromised patients [J]. Support Care Cancer, 2013,21(10):2733-2742.
2016, Vol. 33 
